Hot sale Liquiritin Buy High quality of Liquiritin standard supplier Liquiritin in China
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging:1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition:Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Cas No. | 551-15-5 | SDF | |
PubChem ID | 503737 | Appearance | White powder |
Formula | C21H22O9 | M.Wt | 418.39 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Synonyms | 4',7-Dihydroxyflavanone 4'-glucoside; Liquiritoside | ||
Solubility | DMSO : 150 mg/mL (358.52 mM; Need ultrasonic) | ||
Chemical Name | (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one | ||
SMILES | C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O | ||
Standard InChIKey | DEMKZLAVQYISIA-ZRWXNEIDSA-N | ||
Standard InChI | InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
The root of Glycyrrhiza glabra L.
Description | Liquiritin possesses antidepressant-like, neuroprotective , antioxidant, antiapoptosis, anti-inflammatory and anti-cancer abilities. Liquiritin can attenuate advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells, it may be a promising agent for the treatment of vasculopathy in diabetic patients. |
Targets | GSK-3 | ERK | Akt | NF-kB | 5-HT Receptor | RAGE |
In vitro |
Effect of liquiritin on human intestinal bacteria growth: metabolism and modulation.[Pubmed: 24616071] Biomed Chromatogr. 2014 Sep;28(9):1271-7. Licorice is one of the oldest and most frequently used prescribed traditional Chimese medicines. However, the route and metabolites of Liquiritin by human intestinal microflora are not well understood and its metabolites may accumulate to exert physiological effects. Liquiritin attenuates advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells.[Pubmed: 23229233] Mol Cell Biochem. 2013 Feb;374(1-2):191-201. Advanced glycation end products (AGEs)-induced vasculopathy, including oxidative stress, inflammation and apoptosis responses, contributes to the high morbidity and mortality of coronary artery diseases in diabetic patients. |
In vivo |
Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice.[Pubmed: 18289754] Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1179-84.
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Kinase Assay |
Liquiritin modulates ERK? and AKT/GSK?3β?dependent pathways to protect against glutamate?induced cell damage in differentiated PC12 cells.[Pubmed: 24888902] Mol Med Rep. 2014 Aug;10(2):818-24. Glutamate has a key role in the neuronal cell damage associated with Alzheimer's and Parkinson's diseases. Liquiritin (LQ), a major constituent of Glycyrrhiza Radix, possesses various pharmacological activities. |
Cell Research |
Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells.[Pubmed: 19789989] Cytotechnology. 2009 Jul;60(1-3):125-32. Neurite outgrowth and neuronal differentiation play a crucial role in the development of the nervous system. Understanding of neurotrophins induced neurite outgrowth was important to develop therapeutic strategy for axon regeneration in neurodegenerative diseases as well as after various nerve injuries. It has been reported that extension of neurite and differentiation of sympathetic neuron-like phenotype was modulated by nerve growth factor (NGF) in PC12 cells. |
Animal Research |
Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties.[Pubmed: 21128146 ] J Asian Nat Prod Res. 2010 Dec;12(12):1051-60.
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1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | 47.8023 mL | 59.7529 mL |
5 mM | 0.478 mL | 2.3901 mL | 4.7802 mL | 9.5605 mL | 11.9506 mL |
10 mM | 0.239 mL | 1.1951 mL | 2.3901 mL | 4.7802 mL | 5.9753 mL |
50 mM | 0.0478 mL | 0.239 mL | 0.478 mL | 0.956 mL | 1.1951 mL |
100 mM | 0.0239 mL | 0.1195 mL | 0.239 mL | 0.478 mL | 0.5975 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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