Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
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| 10 Milligram |
Negotiable |
- Min.Order :10 Milligram
- Purity: ≥98%
- Payment Terms : T/T
Keywords
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose 205370-59-8 standard supplier in China
Quick Details
- Appearance:detailed see specifications
- Application:analysis,activity test,Botanical Reference Materials,Standard materials
- PackAge:According to the clients requirement.
- ProductionCapacity:1|Metric Ton|Day
- Storage:Store at 2~8°C
- Transportation:by air or by ocean shipping
Superiority:
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
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D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
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1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
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General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details:
Chemical Properties of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
| Cas No. | 205370-59-8 | ||
| PubChem ID | 85263086 | Appearance | Powder |
| Formula | C42H32O21 | M.Wt | 872.7 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1C(OC2=CC(=CC(=C2C1=O)O)OC3C(C(C4C(O3)COC(=O)C5=CC(=C(C(=C5C6=C(C(=C(C=C6C(=O)O4)O)O)O)O)O)O)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)C8=CC=CC=C8 | ||
| Standard InChIKey | HJEXOQUMFMERIM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C42H32O21/c43-19-8-16(9-26-30(19)20(44)12-25(60-26)14-4-2-1-3-5-14)59-42-36(54)38(63-39(55)15-6-21(45)31(49)22(46)7-15)37-27(61-42)13-58-40(56)17-10-23(47)32(50)34(52)28(17)29-18(41(57)62-37)11-24(48)33(51)35(29)53/h1-11,25,27,36-38,42-43,45-54H,12-13H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Source of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
The herbs of Lindera strychnifolia
Biological Activity of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
| Description | 1. Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml. |
Preparing Stock Solutions of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.1459 mL | 5.7293 mL | 11.4587 mL | 22.9174 mL | 28.6467 mL |
| 5 mM | 0.2292 mL | 1.1459 mL | 2.2917 mL | 4.5835 mL | 5.7293 mL |
| 10 mM | 0.1146 mL | 0.5729 mL | 1.1459 mL | 2.2917 mL | 2.8647 mL |
| 50 mM | 0.0229 mL | 0.1146 mL | 0.2292 mL | 0.4583 mL | 0.5729 mL |
| 100 mM | 0.0115 mL | 0.0573 mL | 0.1146 mL | 0.2292 mL | 0.2865 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
References on Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense.[Pubmed:25620384]
J Ethnopharmacol. 2015 Apr 2;163:256-63.
ETHNOPHARMACOLOGICAL RELEVANCE: Penthorum chinense Pursh has a long history of use as a health food and folk medicine to alleviate "heat"-associated disorders, promote circulation and diuresis, and to treat liver problems, and to protect the spleen. In this study we provide experimental evidence for the clinical use of Penthorum chinense in the treatment of diabetes mellitus. The aim of the study was to investigate the hypoglycemic effects of extracts and active constituents from Penthorum chinense. MATERIALS AND METHODS: High fat diet and STZ (35mg/kg) induced diabetic rats were administered with Penthorum chinense extract at graded oral doses (150 and 300mg/kg/day, ig.) for 2 weeks. A range of parameters, including blood glucose and lipid, serum insulin, glucose tolerance, were tested to evaluate its anti-hyperglycemic effects. Moreover, oral starch tolerance test (OSTT) was performed to test the level of postprandial glucose after administrating Penthorum chinense extract. In vitro study, the Penthorum chinense extracts and purified Penthorum chinense polyphenols were tested for alpha-amylase inhibitory activity. The polyphenols were determined by UPLC-Q-TOF mass spectrometry and NMR. RESULTS: The Penthorum chinense extract possessed anti-hyperglycemic activities as shown by the decreased serum levels of glycosylated hemoglobulin A1C (HbA1c), triglyceride(TG), total cholesterol (TC), and low density lipoprotein-cholesterol (LDL-C), as well as increased serum levels of high density lipoprotein-cholesterol (HDL-C) and insulin. Penthorum chinense extract also improved the oral glucose tolerance test (OGTT) to a certain degree. Moreover, the OSTT study showed that in diabetic rats, the extract (600mg/kg) caused a significant hypoglycemic effect with a blood glucose reduction of 42% at 60min. To identify the active constituents, three polyphenols, pinocembrin-7-O-[4'',6''-hexahydroxydiphenoyl]-beta-d-glucose (1), pinocembrin-7-O-[3''-O-galloyl-4'', 6''-hexahydroxydiphenoyl]-beta- d-glucose (2), and thonningianin A (3) were isolated from Penthorum chinense. Compounds 1-3 moderately inhibited alpha-amylase activity, with IC50 values of 0.14, 0.03, and 0.08micromol/ml, respectively. CONCLUSIONS: The folk medicinal plant, Penthorum chinense produced a moderated anti-hyperglycemic effect on STZ-induced diabetic rats and starch induced postprandial hyperglycemic mice.
Description
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a flavanone compound.
Keywords:
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