Parishin B

Parishin B
Parishin B
Parishin B
Parishin B
Parishin B

Parishin B

Min.Order / FOB Price:Get Latest Price

10 Milligram

Negotiable

  • Min.Order :10 Milligram
  • Purity: ≥98%
  • Payment Terms : T/T

Keywords

Parishin B 174972-79-3 standard supplier in China

Quick Details

  • Appearance:detailed see specifications
  • Application:analysis,activity test,Botanical Reference Materials,Standard materials
  • PackAge:According to the clients requirement.
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:Store at 2~8°C
  • Transportation:by air or by ocean shipping

Superiority:

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers. 
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
 
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
 

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details:

Chemical Properties of Parishin B

Cas No. 174972-79-3    
PubChem ID 44715528 Appearance White powder
Formula C32H40O19 M.Wt 728.7
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in methan
Chemical Name 3-hydroxy-5-oxo-5-[[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methoxy]-3-[[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methoxycarbonyl]pentanoic acid
SMILES C1=CC(=CC=C1COC(=O)CC(CC(=O)O)(C(=O)OCC2=CC=C(C=C2)OC3C(C(C(C(O3)CO)O)O)O)O)OC4C(C(C(C(O4)CO)O)O)O
Standard InChIKey UNLDMOJTKKEMOG-IWOWLDPGSA-N
Standard InChI InChI=1S/C32H40O19/c33-11-19-23(38)25(40)27(42)29(50-19)48-17-5-1-15(2-6-17)13-46-22(37)10-32(45,9-21(35)36)31(44)47-14-16-3-7-18(8-4-16)49-30-28(43)26(41)24(39)20(12-34)51-30/h1-8,19-20,23-30,33-34,38-43,45H,9-14H2,(H,35,36)/t19-,20-,23-,24-,25+,26+,27-,28-,29-,30-,32?/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Parishin B

The rhizomes of Gastrodia elata

Biological Activity of Parishin B

Description Parishin B has good neuroprotective effects against brain disorders, it can prevent vascular dementia.
Targets VEGFR
In vivo

Study on active ingredient and mechanism in preventing vascular dementia of Tianzhusan coming from Tujia medicine.[Pubmed: 26697697]

Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2668-73.


METHODS AND RESULTS:
To make clear of the absorbed components of Tianzhusan (TZS) and its possible mechanism in preventing vascular dementia (VD), the rats' models of VD were prepared by a permanent ligation of the bilateral common carotid arteries. After 60 days, rats were administrated with TZS for 0.1 g x kg(-1), and the volume is 0.02 mL x g(-1). After 3 days, the medicated serum was prepared and detected by UPLC, and then we predicted the possible chemical structure of the absorbed components of TZS. According to the absorbed components, the potential targets of TZS were found by ligand profiling of Discovery Studio 3.5. All of these target genes were submitted to DAVID onine for gene set enrichment analysis (GSEA). The 5 absorbed components of TZS have been predicted, and four of them have been identified as Parishin B, parishin C, parishin, pennogenin-3-O-alpha-L-rhamnopyranosy-(1-->2)-beta-D-glucoside. Through reverse finding targets, we got 861 pharmacophore models and 9 pathways from KEGG, BIOCARTA after document verification.
CONCLUSIONS:
These results showed that the efficacy mechanism of TZS on VD perhaps were be related with these absorbed components and pathways. If the traditional herbs could be proved effective by efficacy tests, the serum pharmacochemistry, computer-aided drug design, system biology and other technologies can be used in the next experiments, which will be beneficial to fast discovery of material basis and mechanisms of traditional medicine coming form ethnic minorities.

Protocol of Parishin B

Structure Identification

Chinese Pharmaceutical Journal, 2001 , 53 (2) :63-69.

The contents of parishin, parishin B and parishin C in traditional decoctions and commercial extracts of Gastrodiae Rhizoma[Reference: WebLink]


METHODS AND RESULTS:
The contents of parishin, Parishin B and parishin C in six traditional decoctions and six commercial extracts of Gastrodiae Rhizoma were analyzed by high performance liquid chromatography. Separation and quantitation were performed on a Cosmosil 5C18-AR column by gradient elution with varied ratios of 0.1 % (v/v) phosphoric acid: methanol as the mobile phase at a flow rate of 1.0 mL/min and detection at 222 nm. Sulfamethoxypyridazine was used as the internal standard. The contents of parishin, Parishin B and parishin C in traditional decoctions of Gastrodiae Rhizoma were 2.7±0.5 mg/g, 2.3 ± 0.2 mg/g and 1.6 ± 0.3 mg/g, whereas commercial extracts contained 6.9± 0.9 mg/g, 2.7± 0.3 mg/g and 1.6± 0.1 mg/g, respectively. Based on our results, the maximum daily doses of parishin, Parishin Band parishin C in traditional decoctions of Gastrodiae Rhizoma were 24.1± 4.5 mg, 20.4± 2.0 mg and 14.4± 2.6 mg compared to 15.6± 1.4 mg, 6.5± 1.1 mg and 4.1± 0.7 mg in commercial extracts, respectively.
CONCLUSIONS:
The daily dose of parishin, Parishin Band parishin C were higher in traditional decoctions than in commercial extracts.

Chinese Journal of Experimental Traditional Medical Formulae, 2016, (18) :5-8.

Comparison on Chemical Constituents and Pharmacological Effect of Gastrodiae Rhizoma Between Traditional Processing and Integration Processing[Reference: WebLink]

To elucidate the rationality of integration processing technology based on comparison on chemical constituents and pharmacological effect of Gastrodiae Rhizoma between traditional processing and integration processing.
METHODS AND RESULTS:
Taking contents of gastrodin and parishins as indexes,chemical constituents difference in Gastrodiae Rhizoma between traditional processing and integration processing was compared,effects of Gastrodiae Rhizoma on eclampsia model induced by pentylenetetrazole were observed to compare products with different processing technology. Contents of gastrodin,parishin A,Parishin B,parishin C and parishin E in products of integration processing were 0. 79%,2. 04%,0. 91%,0. 23% and0. 57%,they were 0. 39%,1. 12%,0. 64%,0. 15% and 0. 54% in products of traditional processing. The anti-eclampsia effect of Gastrodiae Rhizoma produced with integrated processing technology was better thantraditional processing technology.
CONCLUSIONS:
Compared with the traditional processing technology, the integrated processing technology is better in guaranteeing the quality of pieces,reducing the cost of production and increasing the production efficiency.

Preparing Stock Solutions of Parishin B

  1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3723 mL 6.8615 mL 13.7231 mL 27.4461 mL 34.3077 mL
5 mM 0.2745 mL 1.3723 mL 2.7446 mL 5.4892 mL 6.8615 mL
10 mM 0.1372 mL 0.6862 mL 1.3723 mL 2.7446 mL 3.4308 mL
50 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.5489 mL 0.6862 mL
100 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.2745 mL 0.3431 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

 

References on Parishin B

Study on active ingredient and mechanism in preventing vascular dementia of Tianzhusan coming from Tujia medicine.[Pubmed:26697697]

Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2668-73.

To make clear of the absorbed components of Tianzhusan (TZS) and its possible mechanism in preventing vascular dementia (VD), the rats' models of VD were prepared by a permanent ligation of the bilateral common carotid arteries. After 60 days, rats were administrated with TZS for 0.1 g x kg(-1), and the volume is 0.02 mL x g(-1). After 3 days, the medicated serum was prepared and detected by UPLC, and then we predicted the possible chemical structure of the absorbed components of TZS. According to the absorbed components, the potential targets of TZS were found by ligand profiling of Discovery Studio 3.5. All of these target genes were submitted to DAVID onine for gene set enrichment analysis (GSEA). The 5 absorbed components of TZS have been predicted, and four of them have been identified as Parishin B, parishin C, parishin, pennogenin-3-O-alpha-L-rhamnopyranosy-(1-->2)-beta-D-glucoside. Through reverse finding targets, we got 861 pharmacophore models and 9 pathways from KEGG, BIOCARTA after document verification. These results showed that the efficacy mechanism of TZS on VD perhaps were be related with these absorbed components and pathways. If the traditional herbs could be proved effective by efficacy tests, the serum pharmacochemistry, computer-aided drug design, system biology and other technologies can be used in the next experiments, which will be beneficial to fast discovery of material basis and mechanisms of traditional medicine coming form ethnic minorities.

Description

Parishin B, a parishin derivative isolated from Gastrodia elata, may have antioxidant property.

Keywords:

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