- Min.Order :10 Milligram
- Purity: ≥98%
- Payment Terms : T/T
Keywords
Peiminine 18059-10-4 standard supplier in China
Quick Details
- Appearance:detailed see specifications
- Application:analysis,activity test,Botanical Reference Materials,Standard materials
- PackAge:According to the clients requirement.
- ProductionCapacity:1|Metric Ton|Day
- Storage:Store at 2~8°C
- Transportation:by air or by ocean shipping
Superiority:
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
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5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details:
Chemical Properties of Peiminine
| Cas No. | 18059-10-4 | ||
| PubChem ID | 167691 | Appearance | Powder |
| Formula | C27H43NO3 | M.Wt | 429.64 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | Verticinone; Raddeanine | ||
| Solubility | DMSO : ≥ 100 mg/mL (232.75 mM) *"≥" means soluble, but saturation unknown. |
||
| SMILES | CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O | ||
| Standard InChIKey | IQDIERHFZVCNRZ-YUYPDVIUSA-N | ||
| Standard InChI | InChI=1S/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,25-,26+,27-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Source of Peiminine
The bulbus of Fritillaria thunbergii Miq.
Biological Activity of Peiminine
| Description | Peiminine has potent anti-inflammatory, anti-allergic, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth. Peiminine can inhibit lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL. |
| Targets | IFN-γ | TGF-β/Smad | ERK | NF-kB | TNF-α | IL Receptor | MAPK | FasL |
| In vitro |
Antiallergic effects of peiminine through the regulation of inflammatory mediators in HMC-1 cells.[Pubmed: 26121924] Immunopharmacol Immunotoxicol. 2015;37(4):351-8. Peiminine is the main biologically active component derived from Fritillaria ussuriensis. Peiminine was investigated in various pulmonary diseases, but its antiallergic effect and the related mechanism have not been reported yet. The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death.[Pubmed: 25935480 ] Biochem Biophys Res Commun. 2015 Jun 19;462(1):38-45. Autophagy is evolutionarily conservative in eukaryotic cells that engulf cellular long-lived proteins and organelles, and it degrades the contents through fusion with lysosomes, via which the cell acquires recycled building blocks for the synthesis of new molecules. |
Protocol of Peiminine
| Animal Research |
Peiminine ameliorates bleomycin-induced acute lung injury in rats.[Pubmed: 23404624] Mol Med Rep. 2013 Apr;7(4):1103-10. The aim of this study was to investigate whether or not Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury. |
Preparing Stock Solutions of Peiminine
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3275 mL | 11.6377 mL | 23.2753 mL | 46.5506 mL | 58.1883 mL |
| 5 mM | 0.4655 mL | 2.3275 mL | 4.6551 mL | 9.3101 mL | 11.6377 mL |
| 10 mM | 0.2328 mL | 1.1638 mL | 2.3275 mL | 4.6551 mL | 5.8188 mL |
| 50 mM | 0.0466 mL | 0.2328 mL | 0.4655 mL | 0.931 mL | 1.1638 mL |
| 100 mM | 0.0233 mL | 0.1164 mL | 0.2328 mL | 0.4655 mL | 0.5819 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
References on Peiminine
Antiallergic effects of peiminine through the regulation of inflammatory mediators in HMC-1 cells.[Pubmed:26121924]
Immunopharmacol Immunotoxicol. 2015;37(4):351-8.
Peiminine is the main biologically active component derived from Fritillaria ussuriensis. Peiminine was investigated in various pulmonary diseases, but its antiallergic effect and the related mechanism have not been reported yet. The present study aimed to evaluate the effect of Peiminine on mast cell-mediated allergic inflammation in HMC-1 cells. The pro-inflammatory cytokine production was measured using ELISA, reverse transcription-polymerase chain reaction and nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinases (MAPKs) pathway activation, as determined by Western blot analysis. Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and IL-1beta (IL-1beta). It was shown to have inhibitory effects on MAPKs phosphorylation and NF-B expression in human mast cells (HMC)-1 using Western blot. HMC-1 cells were observed for confirmation of histamine release. Passive cutaneous anaphylaxis (PCA) reactions were evaluated using an animal model and Peiminine demonstrated inhibitory effects on IgE-dependent anaphylaxis. These results suggest that Peiminine has regulatory potential for allergic inflammatory reactions mediated by HMC-1 cells.
The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death.[Pubmed:25935480]
Biochem Biophys Res Commun. 2015 Jun 19;462(1):38-45.
Autophagy is evolutionarily conservative in eukaryotic cells that engulf cellular long-lived proteins and organelles, and it degrades the contents through fusion with lysosomes, via which the cell acquires recycled building blocks for the synthesis of new molecules. In this study, we revealed that Peiminine induces cell death and enhances autophagic flux in colorectal carcinoma HCT-116 cells. We determined that Peiminine enhances the autophagic flux by repressing the phosphorylation of mTOR through inhibiting upstream signals. Knocking down ATG5 greatly reduced the Peiminine-induced cell death in wild-type HCT-116 cells, while treating Bax/Bak-deficient cells with Peiminine resulted in significant cell death. In summary, our discoveries demonstrated that Peiminine represses colorectal carcinoma cell proliferation and cell growth by inducing autophagic cell death.
Peiminine ameliorates bleomycin-induced acute lung injury in rats.[Pubmed:23404624]
Mol Med Rep. 2013 Apr;7(4):1103-10.
The aim of this study was to investigate whether or not Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury. Rats were randomly divided into 4 groups. In 3 groups, intratracheal bleomycin (5 mg/kg) was used to induce acute lung injury, followed by administration of either carboxymethyl cellulose (control group, n=14), dexamethasone (DXS group, n=14) or Peiminine (Peiminine group, n=10). In the fourth group (sham-operated, n=12), normal saline was instilled instead of bleomycin, followed by administration of carboxymethyl cellulose. Drugs were administered intragastrically for 28 days. Lung sections were stained with hematoxylin and eosin (H&E) and Masson's trichrome, to grade the degree of alveolitis and pulmonary fibrosis. The lung index was calculated as the ratio of lung to body weight. Serum levels of interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) were obtained using a radioimmunoassay. Immunocytochemical methods were employed to assess the expression of transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF), NF-kappaB, extracellular signal-related kinase (ERK1/2), Fas and FasL in lung tissue. Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with bleomycin-induced lung injury. These protective effects were associated with significant (P<0.05) decreases in the levels of IFN-gamma in serum and of TGF-beta, CTGF, ERK1/2, NF-kappaB and FasL in lung tissue. No effects were observed on serum TNF-alpha or IL-4. In conclusion, Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-gamma levels and inhibiting signal transduction pathways involving TGF-beta, CTGF, ERK1/2, NF-kappaB and FasL.
Description
Peiminine(Verticinone; Raddeanine) is a natural compound with anti-inflammatory activity.
Keywords:
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