- Min.Order :10 Milligram
- Purity: ≥98%
- Payment Terms : T/T
Keywords
L-Menthol 2216-51-5 standard supplier in China
Quick Details
- Appearance:detailed see specifications
- Application:analysis,activity test,Botanical Reference Materials,Standard materials
- PackAge:According to the clients requirement.
- ProductionCapacity:1|Metric Ton|Day
- Storage:Store at 2~8°C
- Transportation:by air or by ocean shipping
Superiority:
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details:
Chemical Properties of L-Menthol
| Cas No. | 2216-51-5 | ||
| PubChem ID | 16666 | Appearance | Colorless crystals |
| Formula | C10H20O | M.Wt | 156.27 |
| Type of Compound | Monoterpenoids | Storage | Desiccate at -20°C |
| Synonyms | L-Menthol; (-)-Menthol; Levomenthol; 89-78-1; Menthomenthol; L-(-)-Menthol; Hexahydrothymol | ||
| Solubility | DMSO : 100 mg/mL (639.92 mM; Need ultrasonic) | ||
| Chemical Name | (1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol | ||
| SMILES | CC1CCC(C(C1)O)C(C)C | ||
| Standard InChIKey | NOOLISFMXDJSKH-KXUCPTDWSA-N | ||
| Standard InChI | InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Source of L-Menthol
The herbs of Mentha canadensis L.
Biological Activity of L-Menthol
| Description | Menthol is used in analgesic balms and also in foods and oral hygiene products for its fresh cooling sensation, menthol enhances cooling by interacting with the cold-sensitive thermoTRP channel TRPM8. L-Menthol has antiperistaltic and anti-inflammatory effects, clinical trials investigating the potential therapeutic efficacy of L-menthol for treatment of chronic inflammatory disorders such as bronchial asthma, colitis and allergic rhinitis seem worthwhile, it sprayed on the gastric mucosa significantly suppresses peristalsis with minimal adverse drug reactions during upper GI endoscopy. |
| Targets | PGE | IL Receptor | LTB |
| In vitro |
The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.[Pubmed: 9889172] Eur J Med Res. 1998 Dec 16;3(12):539-45. The anti-inflammatory efficacy of monoterpenes is still unknown. In order to evaluate the potential role of L-Menthol and mint oil as an anti-inflammatory drug, preclinical in vitro-investigations were performed using LPS-stimulated monocytes from healthy volunteers. |
| In vivo |
L-menthol improves adenoma detection rate during colonoscopy: a randomized trial.[Pubmed: 24573731] Endoscopy. 2014 Mar;46(3):196-202. Colonoscopy is one of the most reliable methods for the detection of colorectal neoplasms. However, colonic peristalsis during colonoscopy results in some neoplastic lesions being hidden from view and commonly requires an intravenous or intramuscular injection of antispasmodic agents, which may sometimes causes unexpected adverse reactions. The aim of this study was to evaluate the efficacy of L-Menthol spray as an antiperistaltic agent and its effect on adenoma detection. Relieving thermal discomfort: Effects of sprayed L-menthol on perception, performance, and time trial cycling in the heat.[Pubmed: 25943672] Scand J Med Sci Sports. 2015 Jun;25 Suppl 1:211-8. L-Menthol stimulates cutaneous thermoreceptors and induces cool sensations improving thermal comfort, but has been linked to heat storage responses; this could increase risk of heat illness during self-paced exercise in the heat.Therefore, L-Menthol application could lead to a discrepancy between behavioral and autonomic thermoregulatory drivers. Antiperistaltic effect and safety of L-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study.[Pubmed: 21353674 ] Gastrointest Endosc. 2011 May;73(5):932-41. GI peristalsis during GI endoscopy commonly requires intravenous or intramuscular injection of antispasmodic agents, which sometimes cause unexpected adverse reactions. Our ultimate goal was to evaluate whether the antiperistaltic effect of L-Menthol-based preparations facilitates endoscopic examinations in a clinical setting. |
Preparing Stock Solutions of L-Menthol
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.3992 mL | 31.9959 mL | 63.9918 mL | 127.9836 mL | 159.9795 mL |
| 5 mM | 1.2798 mL | 6.3992 mL | 12.7984 mL | 25.5967 mL | 31.9959 mL |
| 10 mM | 0.6399 mL | 3.1996 mL | 6.3992 mL | 12.7984 mL | 15.998 mL |
| 50 mM | 0.128 mL | 0.6399 mL | 1.2798 mL | 2.5597 mL | 3.1996 mL |
| 100 mM | 0.064 mL | 0.32 mL | 0.6399 mL | 1.2798 mL | 1.5998 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
References on L-Menthol
The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.[Pubmed:9889172]
Eur J Med Res. 1998 Dec 16;3(12):539-45.
The anti-inflammatory efficacy of monoterpenes is still unknown. In order to evaluate the potential role of L-Menthol and mint oil as an anti-inflammatory drug, preclinical in vitro-investigations were performed using LPS-stimulated monocytes from healthy volunteers. Arachidonic acid metabolism was assessed by measuring LTB subset4 and PGE subset2 as indicators for both the lipoxygenase and the cyclooxygenase pathways respectively. In addition, the anti-inflammatory effects of the two terpenes on IL-1beta production were analysed. - L-Menthol significantly suppressed the production of each of the three inflammation mediators by monocytes in vitro. LTB subset4 decreased by -64.4 +/- 10%, PGE subset2 by -56.6 +/- 8%, and IL-1beta by -64.2 +/- 7% respectively at L-Menthol concentrations within the presumed therapeutic range of about 10 superset-7 g/ml. In contrast, mint oil had a bimodal effect on PGE subset2 production: lower concentrations of 10 superset-10 to 10 superset-8 g/ml increased PGE subset2 up to 6-fold compared to baseline but concentrations of 10 superset-7 g/ml suppressed PGE subset2 production by approximately 50%. Mint oil had similar effects on LTB subset4 and IL-1beta as its main constituent, L-Menthol, although the degree of suppression was by comparison smaller at lower concentrations. Paraffin oil, which served as a solvent, did not affect arachidonic acid metabolism and IL-1beta production. - These results obtained with human monocytes suggest preferable anti-inflammatory effects of L-Menthol compared to mint oil at therapeutically relevant concentrations supplied in enteric coated capsules. Therefore, clinical trials investigating the potential therapeutic efficacy of L-Menthol for treatment of chronic inflammatory disorders such as bronchial asthma, colitis and allergic rhinitis seem worthwhile.
Antiperistaltic effect and safety of L-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study.[Pubmed:21353674]
Gastrointest Endosc. 2011 May;73(5):932-41.
BACKGROUND: GI peristalsis during GI endoscopy commonly requires intravenous or intramuscular injection of antispasmodic agents, which sometimes cause unexpected adverse reactions. OBJECTIVE: Our ultimate goal was to evaluate whether the antiperistaltic effect of L-Menthol-based preparations facilitates endoscopic examinations in a clinical setting. DESIGN: Multicenter, randomized, double-blind, placebo-controlled study. SETTING: Six Japanese referral centers. PATIENTS AND INTERVENTION: A total of 87 patients scheduled to undergo upper GI endoscopy were randomly assigned to receive 160 mg of L-Menthol (n=45) or placebo (n=42). Both treatments were sprayed endoscopically on the gastric mucosa. The degree of gastric peristalsis was assessed by an independent committee. MAIN OUTCOME MEASUREMENTS: The proportion of subjects with no peristalsis 90 to 135 seconds after administration and at the end of the endoscopic examination (complete suppression of gastric peristalsis). Other outcomes were the proportion of subjects with no or mild peristalsis (adequate suppression of gastric peristalsis) and the ease of intragastric observation as evaluated by the endoscopist who performed the procedure. RESULTS: Gastric peristalsis was completely suppressed in 35.6% (21.9, 51.2) of the L-Menthol group compared with only 7.1% (1.5, 19.5) of the placebo group (P<.001). In the L-Menthol group, 77.8% (62.9, 88.8) (35/45 subjects) of the subjects had no or mild peristalsis at the completion of endoscopy. Minor peristalsis interfered with intragastric examination in only 1 of these 35 patients (2.9%). The incidence of adverse events did not differ significantly between the groups (P=.512). LIMITATION: Small sample size. CONCLUSIONS: During upper GI endoscopy, L-Menthol sprayed on the gastric mucosa significantly suppresses peristalsis with minimal adverse drug reactions compared with placebo. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT00742599.).
Relieving thermal discomfort: Effects of sprayed L-menthol on perception, performance, and time trial cycling in the heat.[Pubmed:25943672]
Scand J Med Sci Sports. 2015 Jun;25 Suppl 1:211-8.
L-Menthol stimulates cutaneous thermoreceptors and induces cool sensations improving thermal comfort, but has been linked to heat storage responses; this could increase risk of heat illness during self-paced exercise in the heat. Therefore, L-Menthol application could lead to a discrepancy between behavioral and autonomic thermoregulatory drivers. Eight male participants volunteered. They were familiarized and then completed two trials in hot conditions (33.5 degrees C, 33% relative humidity) where their t-shirt was sprayed with CONTROL-SPRAY or MENTHOL-SPRAY after 10 km (i.e., when they were hot and uncomfortable) of a 16.1-km cycling time trial (TT). Thermal perception [thermal sensation (TS) and comfort (TC)], thermal responses [rectal temperature (Trec ), skin temperature (Tskin )], perceived exertion (RPE), heart rate, pacing (power output), and TT completion time were measured. MENTHOL-SPRAY made participants feel cooler and more comfortable and resulted in lower RPE (i.e., less exertion) yet performance was unchanged [TT completion: CONTROL-SPRAY 32.4 (2.9) and MENTHOL-SPRAY 32.7 (3.0) min]. Trec rate of increase was 1.40 (0.60) and 1.45 (0.40) degrees C/h after CONTROL-SPRAY and MENTHOL-SPRAY application, which were not different. Spraying L-Menthol toward the end of self-paced exercise in the heat improved perception, but did not alter performance and did not increase heat illness risk.
L-menthol improves adenoma detection rate during colonoscopy: a randomized trial.[Pubmed:24573731]
Endoscopy. 2014 Mar;46(3):196-202.
BACKGROUND AND STUDY AIMS: Colonoscopy is one of the most reliable methods for the detection of colorectal neoplasms. However, colonic peristalsis during colonoscopy results in some neoplastic lesions being hidden from view and commonly requires an intravenous or intramuscular injection of antispasmodic agents, which may sometimes causes unexpected adverse reactions. The aim of this study was to evaluate the efficacy of L-Menthol spray as an antiperistaltic agent and its effect on adenoma detection. PATIENTS AND METHODS: This was a prospective, randomized, single-blind placebo-controlled trial. A total of 226 patients who were scheduled to undergo colonoscopy were randomly assigned to receive either 20 mL of 1.6 % L-Menthol (n = 118) or placebo (n = 108). Both treatments were sprayed locally onto the colonic mucosa via an endoscope. The adenoma detection rate (ADR) and the proportion of patients with no peristalsis were the primary and secondary outcomes, respectively. RESULTS: The ADR was significantly higher in the L-Menthol group than in the placebo group (60.2 % vs. 42.6 %; P = 0.0083). The proportion of patients with no peristalsis after treatment with L-Menthol was significantly higher than in the placebo group (71.2 % vs. 30.9 %; P < 0.0001). There were no adverse effects in either group. CONCLUSIONS: The results suggest that the suppression of colonic peristalsis by L-Menthol sprayed directly onto the colonic mucosa improves the ADR. CLINICAL TRIAL REGISTRATION: ID: UMIN 000007972.
Description
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i. Antitumor activity.
Keywords:
L-Menthol,2216-51-5,L-Menthol; (-)-Menthol; Levomenthol; 89-78-1; Menthomenthol; L-(-)-Menthol; Hexahydrothymol,Natural Products, buy L-Menthol , L-Menthol supplier , purchase L-Menthol , L-Menthol cost , L-Menthol manufacturer , order L-Menthol , high purity L-Menthol
You Might Also Like
Related Searches
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View