- Min.Order :10 Milligram
- Purity: ≥98%
- Payment Terms : T/T
Keywords
Griffonilide 61371-55-9 standard supplier in China
Quick Details
- Appearance:detailed see specifications
- Application:analysis,activity test,Botanical Reference Materials,Standard materials
- PackAge:According to the clients requirement.
- ProductionCapacity:1|Metric Ton|Day
- Storage:Store at 2~8°C
- Transportation:by air or by ocean shipping
Superiority:
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details:
Chemical Properties of Griffonilide
| Cas No. | 61371-55-9 | ||
| PubChem ID | 324687 | Appearance | White powder |
| Formula | C8H8O4 | M.Wt | 168.04 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in methanol and water | ||
| Chemical Name | 6,7-dihydroxy-7,7a-dihydro-6H-1-benzofuran-2-one | ||
| SMILES | C1=CC2=CC(=O)OC2C(C1O)O | ||
| Standard InChIKey | VXWUBYBAUIHOHG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H8O4/c9-5-2-1-4-3-6(10)12-8(4)7(5)11/h1-3,5,7-9,11H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Source of Griffonilide
1 Semiaquilegia sp.
Biological Activity of Griffonilide
| Description | Griffonilide is islolated from the tubers of Tylosema esculentum (morama). |
| In vitro |
Therapeutic and Prophylactic Potential of Morama (Tylosema esculentum): A Review.[Pubmed: 26206567] Phytother Res. 2015 Jul 21. Tylosema esculentum (morama) is a highly valued traditional food and source of medicine for the San and other indigenous populations that inhabit the arid to semi-arid parts of Southern Africa. |
Protocol of Griffonilide
| Structure Identification |
Bioorg Med Chem. 2011 Sep 1;19(17):5225-30. Tylosema esculentum extractives and their bioactivity.[Pubmed: 21813280]
|
Preparing Stock Solutions of Griffonilide
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.951 mL | 29.7548 mL | 59.5096 mL | 119.0193 mL | 148.7741 mL |
| 5 mM | 1.1902 mL | 5.951 mL | 11.9019 mL | 23.8039 mL | 29.7548 mL |
| 10 mM | 0.5951 mL | 2.9755 mL | 5.951 mL | 11.9019 mL | 14.8774 mL |
| 50 mM | 0.119 mL | 0.5951 mL | 1.1902 mL | 2.3804 mL | 2.9755 mL |
| 100 mM | 0.0595 mL | 0.2975 mL | 0.5951 mL | 1.1902 mL | 1.4877 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations | |||||
References on Griffonilide
Therapeutic and Prophylactic Potential of Morama (Tylosema esculentum): A Review.[Pubmed:26206567]
Phytother Res. 2015 Oct;29(10):1423-38.
Tylosema esculentum (morama) is a highly valued traditional food and source of medicine for the San and other indigenous populations that inhabit the arid to semi-arid parts of Southern Africa. Morama beans are a rich source of phenolic acids, flavonoids, certain fatty acids, non-essential amino acids, certain phytosterols, tannins and minerals. The plant's tuber contains Griffonilide, behenic acid and starch. Concoctions of extracts from morama bean, tuber and other local plants are frequently used to treat diarrhoea and digestive disorders by the San and other indigenous populations. Information on composition and bioactivity of phytochemical components of T. esculentum suggests that the polyphenol-rich extracts of the bean testae and cotyledons have great potential as sources of chemicals that inhibit infectious microorganisms (viral, bacterial and fungal, including drug-resistant strains), offer protection against certain non-communicable diseases and promote wound healing and gut health. The potential antinutritional properties of a few morama components are also highlighted. More research is necessary to reveal the full prophylactic and therapeutic potential of the plant against diseases of the current century. Research on domestication and conservation of the plant offers new hope for sustainable utilisation of the plant.
Tylosema esculentum extractives and their bioactivity.[Pubmed:21813280]
Bioorg Med Chem. 2011 Sep 1;19(17):5225-30.
The investigation of Tylosema esculentum (Morama) husks, cotyledons, and tuber yielded Griffonilide 2, compound 1, griffonin 3, gallic acid 4, protocatechuic acid 5, beta-sitosterol 6, behenic acid 7, oleic acid 8, sucrose 9, 2-O-ethyl-alpha-D-glucopyranoside 10, kaempferol 11 and kaempferol-3-O-beta-D-glucopyranoside 12. The structures of the isolates were determined by NMR, HR-TOF EIMS, IR and UV-vis spectroscopy, and by comparison with literature data. The husk EtOAc and n-butanol extracts demonstrated >90% DPPH radical scavenging activity at concentrations of 25, 50 and 250 mug/mL. Furthermore the husk extracts showed higher total phenolic content (233 mg GAE/g). The extractives exhibited minimum inhibitory quantities of 50-100 mug or no activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans. The tuber extracts were inactive against Caco-2 and Hela cell lines, while the husk extracts showed low activity against Caco-2 and Vero cell line with IC(50) values >400 mug/mL. The GC-MS analysis showed the beans and tuber non-polar (n-hexane) extracts major constituents as fatty acids.
Constituents from the roots of Semiaquilegia adoxoides.[Pubmed:11163952]
Fitoterapia. 2001 Jan;72(1):86-8.
The isolation of Griffonilide (1), lithospermoside (2) and magnoflorine (3) from the roots of Semiaquilegia adoxoides is reported.
Description
Griffonilide is a butenolide, isolated from the roots of Semiaquilegia adoxoides, and often occurs alongside lithospermoside.
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