Phenethyl caffeate

Min.Order / FOB Price:Get Latest Price

10 Milligram	Negotiable

10 Milligram

Negotiable

Min.Order :10 Milligram
Purity: ≥98%
Payment Terms : T/T

Keywords

Phenethyl caffeate 104594-70-9 standard supplier in China

Quick Details

Appearance:detailed see specifications
Application:analysis,activity test,Botanical Reference Materials,Standard materials
PackAge:According to the clients requirement.
ProductionCapacity:1|Metric Ton|Day
Storage:Store at 2~8°C
Transportation:by air or by ocean shipping

Superiority:

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details:

Chemical Properties of Caffeic acid phenethyl ester

Cas No.	104594-70-9	SDF
PubChem ID	5281787	Appearance	Powder
Formula	C₁₇H₁₆O₄	M.Wt	284.31
Type of Compound	Phenylpropanoids	Storage	Desiccate at -20°C
Synonyms	CAPE
Solubility	DMSO : 150 mg/mL (527.59 mM; Need ultrasonic and warming) H2O : < 0.1 mg/mL (insoluble)
Chemical Name	2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES	C1=CC=C(C=C1)CCOC(=O)C=CC2=CC(=C(C=C2)O)O
Standard InChIKey	SWUARLUWKZWEBQ-VQHVLOKHSA-N
Standard InChI	InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Caffeic acid phenethyl ester

The barks of Cinnamomum cassia Presl

Biological Activity of Caffeic acid phenethyl ester

Description	Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays neuroprotective, antioxidant, immunomodulatory and antiinflammatory activities; it also has potential beneficial effects on the wound healing of nasal mucosa in the rat.Caffeic acid phenethyl ester has potential preventive effects on myringosclerosis development after myringotomy and ventilation tube insertion.
Targets	NF-κB \| IL Receptor \| MCP-1 \| ICAM-1 \| Akt
In vitro	Caffeic acid phenethyl ester inhibits the inflammatory effects of interleukin-1β in human corneal fibroblasts.[Pubmed: 25151996] Immunopharmacol Immunotoxicol. 2014 Oct;36(5):371-7. The regulatory mechanisms of Caffeic acid phenethyl ester on cellular signaling pathways were examined using Western blot and electrophoretic mobility shift assays. METHODS AND RESULTS: A functional validation was carried out by evaluating the inhibitory effects of Caffeic acid phenethyl ester on neutrophil and monocyte migration in vitro. Caffeic acid phenethyl ester inhibited the expression of IL-6, MCP-1 and ICAM-1 induced by the pro-inflammatory cytokine IL-1β in corneal fibroblasts. The activation of AKT and NF-κB by IL-1β was markedly inhibited by Caffeic acid phenethyl ester, whereas the activity of mitogen-activated protein kinases (MAPKs) was not affected. Caffeic acid phenethyl ester significantly suppressed the IL-1β-induced migration of differentiated (d)HL-60 and THP-1 cells. CONCLUSIONS: These anti-inflammatory effects of Caffeic acid phenethyl ester may be expected to inhibit the infiltration of leukocytes into the corneal stroma in vivo.
In vivo	Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study.[Pubmed: 24767474] Am J Otolaryngol. 2014 Jul-Aug;35(4):482-6. In this experimental study, our aim was to use histopathological examination to investigate the effects of Caffeic acid phenethyl ester on the wound healing of rat nasal mucosa after mechanical trauma. METHODS AND RESULTS: The rats were randomly divided into 3 experimental groups: a non-treated group (n=7), a control saline group (n=7) and a Caffeic acid phenethyl ester group (n=7). The non-treated group received no treatment for 15 days. The second group was administered saline (2.5 mL/kg, intraperitoneal) once a day for 15 days. The third group received Caffeic acid phenethyl ester intraperitoneally at a dose of 10 μmol/kg once a day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced on the right nasal mucosa of all rats in the three groups using a brushing technique. Samples were stained using hematoxylin and eosin solution and were examined by a pathologist using a light microscope. The severity of inflammation was milder in the Caffeic acid phenethyl ester group compared with that in the non-treated and saline groups (P<0.05). The subepithelial thickness index was lower in the experimental group (P<0.05). Goblet cell and ciliated cell loss was substantially reduced in the experimental group compared with the non-treated and saline groups (P<0.05). CONCLUSIONS: Caffeic acid phenethyl ester decreases inflammation and the loss of goblet cells and ciliated cells. Therefore, Caffeic acid phenethyl ester has potential beneficial effects on the wound healing of nasal mucosa in the rat. Caffeic acid phenethyl ester prevents apoptotic cell death in the developing rat brain after pentylenetetrazole-induced status epilepticus.[Pubmed: 24012504] Epilepsy Behav. 2013 Nov;29(2):275-80. The aim of this study was to investigate whether Caffeic acid phenethyl ester exerts neuroprotective effects on the developing rat brain after status epilepticus. METHODS AND RESULTS: Twenty-one dams reared Wistar male rats, and 21-day-old rats were divided into three groups: control group, pentylenetetrazole-induced status epilepticus group, and Caffeic acid phenethyl ester-treated group. Status epilepticus was induced on the first day of experiment. Caffeic acid phenethyl ester injections (30 mg/kg intraperitoneally) started 40 min after the tonic phase of status epilepticus was reached, and the injections of Caffeic acid phenethyl ester were repeated over 5 days. Rats were sacrificed, and brain tissues were collected on the 5th day of experiment after the last injection of Caffeic acid phenethyl ester. Apoptotic cell death was evaluated. Histopathological examination showed that Caffeic acid phenethyl ester significantly preserved the number of neurons in the CA1, CA3, and dentate gyrus regions of the hippocampus and the prefrontal cortex. It also diminished apoptosis in the hippocampus and the prefrontal cortex. CONCLUSIONS: In conclusion, this experimental study suggests that Caffeic acid phenethyl ester administration may be neuroprotective in status epilepticus in the developing rat brain.

Protocol of Caffeic acid phenethyl ester

Cell Research

Protective effects of caffeic acid phenethyl ester (CAPE) against neomycin-induced hair cell damage in zebrafish.[Pubmed: 24880922]

Int J Pediatr Otorhinolaryngol. 2014 Aug;78(8):1311-5.

Caffeic acid phenethyl ester (CAPE) is known to reduce the generation of oxygen-derived free radicals, which is a major mechanism of aminoglycoside-induced ototoxicity.
METHODS AND RESULTS:
The objective of the present study was to evaluate the effects of Caffeic acid phenethyl ester on neomycin-induced ototoxicity in zebrafish (Brn3c: EGFP). Caffeic acid phenethyl ester decreased neomycin-induced hair cell loss in the neuromasts (500 μM CAPE: 12.7 ± 1.1 cells, 125 μM neomycin only: 6.3 ± 1.1 cells; n = 10, P < 0.05). In the ultrastructural analysis, structures of mitochondria and hair cells were preserved when exposed to 125 μM neomycin and 500 μM Caffeic acid phenethyl ester. Caffeic acid phenethyl ester decreased apoptosis and mitochondrial damage.
CONCLUSIONS:
In the present study, Caffeic acid phenethyl ester attenuated neomycin-induced hair cell damage in zebrafish. The results of the current study suggest that neomycin induces apoptosis, and the apoptotic cell death can be prevented by treatment with Caffeic acid phenethyl ester in zebrafish.

Animal Research

Effect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of rat.[Pubmed: 24281567]

Eur Arch Otorhinolaryngol. 2015 Jan;272(1):29-34.

Our aim was to show the histopathological effects of Caffeic acid phenethyl ester on myringosclerosis development in rat tympanic membrane after myringotomy.
METHODS AND RESULTS:
The rats were randomly categorized into four experimental groups including the comparison group (n = 4), non-treated group (n = 7), the saline (control) group (n = 7), the Caffeic acid phenethyl ester group (n = 7). Non-treated group did not receive any treatment for 15 days. Saline (2.5 mL/kg, intraperitoneal) was administered to the third group once a day for 15 days. Fourth group received Caffeic acid phenethyl ester intraperitoneally once a day at a dose of 10 μmol/kg for 15 days. Myringotomy was performed on the right tympanic membrane of all rats except comparison group using a sterile pick with the help of an operating microscope. Histopathological examination of myringosclerosis formation was done by a pathologist under light microscope. In histopathological analysis of groups, the severity of inflammation was milder in Caffeic acid phenethyl ester group compared to non-treated and saline groups (p < 0.05). There was less myringosclerotic plaques in Caffeic acid phenethyl ester group than in non-treated and saline groups (p < 0.05). TM thickness measurements were very close to each other in non-treated and saline groups. The tympanic membrane thickness of Caffeic acid phenethyl ester group was much thinner than the other two groups (p < 0.05). Caffeic acid phenethyl ester decreases inflammation severity and the formation of myringosclerotic plaques. These two effects resulted in thinner tympanic membranes of rats which were treated with Caffeic acid phenethyl ester.
CONCLUSIONS:
As a result, Caffeic acid phenethyl ester has potential preventive effects on myringosclerosis development after myringotomy and ventilation tube insertion.

Preparing Stock Solutions of Caffeic acid phenethyl ester

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5173 mL	17.5864 mL	35.1729 mL	70.3457 mL	87.9322 mL
5 mM	0.7035 mL	3.5173 mL	7.0346 mL	14.0691 mL	17.5864 mL
10 mM	0.3517 mL	1.7586 mL	3.5173 mL	7.0346 mL	8.7932 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.4069 mL	1.7586 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8793 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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