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CAS 148498-78-6 2023788-19-2 peptide
Tirzepatide CAS 2023788-19-2
Structure
Tirzepatide is an analog of the human GIP hormone with a C20 fatty-diacid portion attached, used to optimise the uptake and metabolism of the compound. The fatty-diacid section (eicosanedioic acid) is linked via a glutamic acid and two (2-(2-aminoethoxy)ethoxy)acetic acid units to the side chain of the lysine residue. This arrangement allows for a much longer half-life, extending the time between doses, because of its high affinity to albumin.
Synthesis
The synthesis of tirzepatide was first disclosed in patents filed by Eli Lilly and Company.This uses standard solid phase peptide synthesis, with an allyloxycarbonyl protecting group on the lysine at position 20 of the linear chain of amino acids, allowing a final set of chemical transformations in which the sidechain amine of that lysine is derivatized with the lipid-containing fragment.
Tirzepatide is indicated to improve blood-sugar control in adults with type 2 diabetes, as an addition to diet and exercise.
Company Introduction
Manhattan Technology Industry Co.,Ltd Mainly engaged in chemical products R & D and production, pharmaceutical intermediates R & D and production Chemical product development and customization, operating in one integrated high-tech enterprises. Unique ability in R&D and innovation of high precision chemicals.The company cooperates with a number of domestic pharmaceutical and chemical research institutes, forming a complete and unique new product technical force team.
To date, Manhattan has established cooperation with trading partners in more than 28 countries, including large buyers from Europe and the Americas. has been at the forefront of the industry. The company has strong technical force, advanced equipment, strict quality management system, quality after-sales service, adhere to the "customer first, forge ahead" business philosophy, adhere to the integrity of the company's survival. Everything for customer satisfaction, everything for the long-term healthy development of the enterprise.
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