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Cetilistat Cetilistat powder Cetilistat supplier
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.
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Product Name: Cetilistat
Synonyms: 4H-3,1-Benzoxazin-4-one,2-(hexadecyloxy)-6-Methyl-;Xinli orlistat;cetilistat;Cetilistat(Alt-962);Cetilstat;Cetilistat (282526-98-1);New alistat;2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one
CAS: 282526-98-1
MF: C25H39NO3
MW: 401.58
Melting point: 72.0 to 76.0℃
Boiling point: 509.7±43.0℃(Predicted)
Density: 1.02
Chemical Properties: Off-white Cryst
Description:
Cetilistat (also known as ATL-962) was approved in September 2013 by the Japanese Ministry of Health, Labor and Welfare for the treatment of obesity, limited to patients with both type 2 diabetes mellitus (T2DM) and dyslipidemia, and with a body mass index (BMI)25 kg/m2 in spite of dietary treatment and/or exercise therapy. As with orlistat, cetilistat works via inhibition of pancreatic lipases in the gut to inhibit fat absorption and thereby reduce caloric uptake from diet. The medicinal chemistry program has not been described in the scientific literature, but the patent describing cetilistat also describes the synthesis of analogs with varied aryl substituents and lipophilic tails. Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC50s of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin.
Uses:
A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.
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Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / Sales Manager
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