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Enzalutamide Enzalutamide powder Enzalutamide ssupplier
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Enzalutamide
Product Name: Enzalutamide
CAS: 915087-33-1
MF: C21H16F4N4O2S
MW: 464.44
EINECS: 805-022-1
Melting point: 198 - 200°C
Density: 1.49
Storage temp.: -20°C
Appearance: white to off-white powder
Description:
In August 2012, the US FDA approved enzalutamide for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously been treated with docetaxel. Synthesis of enzalutamide was achieved by a triply convergent route that employed a Strecker condensation, followed by isothiocyanate condensation and hydrolysis to form the thiohydantoin moiety.
Uses:
In vitro, enzalutamide suppressed proliferation and induced apoptosis in human prostate cancer cell lines. The sensitivity of prostate cancer cells to T cell-mediated lysis via androgen receptor-dependent immunomodulation was enhanced by enzalutamide. Enzalutamide lacked androgen receptor agonist activity in CRPC cell models and induced tumour regression in CRPC xenograft models.
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Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / Sales Manager
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