Uridine 58-96-8 standard supplier in China
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General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging:1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition:Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Cas No. | 58-96-8 | SDF | |
PubChem ID | 6029 | Appearance | Powder |
Formula | C9H12N2O6 | M.Wt | 244.2 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Synonyms | β-Uridine;Uracil riboside;Uridin | ||
Solubility | H2O : ≥ 100 mg/mL (409.50 mM) DMSO : 100 mg/mL (409.50 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. |
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Chemical Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | ||
SMILES | C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O | ||
Standard InChIKey | DRTQHJPVMGBUCF-XVFCMESISA-N | ||
Standard InChI | InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
The herbs of Heracleum stenopterum
Description | Uridine has antidepressant-like effects, and it has protective effects against drug-induced fatty liver. Uridine can increase the rate of potassium transport in mitochondria isolated from liver of low resistant rats, and inhibitors of the channel prevent the channel activating effect of Uridine. Uridine has inhibition of p53-dependent intestinal apoptosis initiated by 5-fluorouracil. |
Targets | ATPase | Potassium Channel | p53 |
In vivo |
The effect of uridine on the endurance of animals with different resistance to physical stress: the role of mitochondrial ATP-dependent potassium channel.[Pubmed: 25730977] Biofizika. 2014 Sep-Oct;59(5):941-5. The effect of a metabolic precursor of natural activator of mitochondrial ATP-dependent potassium channel (mitochondrial K+(ATP))--Uridine on animal's endurance to physical stress was studied. Uridine prevents tamoxifen-induced liver lipid droplet accumulation.[Pubmed: 24887406 ] BMC Pharmacol Toxicol. 2014 May 23;15:27. Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease. Prevention of tamoxifen-induced fatty liver has the potential to improve the safety of long-term tamoxifen usage. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation.[Reference: WebLink] Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5): 1795–1799. The epithelia from the crypts of the intestine are exquisitely sensitive to metabolic perturbation and undergo cell death with the classical morphology of apoptosis. |
Animal Research |
Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats.[Pubmed: 15705349] Biol Psychiatry. 2005 Feb 15;57(4):343-50. Brain phospholipid metabolism and membrane fluidity may be involved in the pathophysiology of mood disorders. We showed previously that cytidine, which increases phospholipid synthesis, has antidepressant-like effects in the forced swim test (FST) in rats, a model used in depression research. Because cytidine and Uridine both stimulate synthesis of cytidine 5'-diphosphocholine (CDP-choline, a critical substrate for phospholipid synthesis), we examined whether Uridine would also produce antidepressant-like effects in rats. We also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with Uridine. |
Structure Identification |
Molecules. 2014 Apr 4;19(4):4313-25. Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand.[Pubmed: 24714193] In this study we report the synthesis of C5/C6-fused Uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. ACS Comb Sci. 2014 May 12;16(5):232-7. Parallel solution-phase synthesis and general biological activity of a uridine antibiotic analog library.[Pubmed: 24661222 ] A small library of ninety four Uridine antibiotic analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from amine 2 and carboxylic acids 33 and 77 in solution-phase fashion. |
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 4.095 mL | 20.475 mL | 40.95 mL | 81.9001 mL | 102.3751 mL |
5 mM | 0.819 mL | 4.095 mL | 8.19 mL | 16.38 mL | 20.475 mL |
10 mM | 0.4095 mL | 2.0475 mL | 4.095 mL | 8.19 mL | 10.2375 mL |
50 mM | 0.0819 mL | 0.4095 mL | 0.819 mL | 1.638 mL | 2.0475 mL |
100 mM | 0.041 mL | 0.2048 mL | 0.4095 mL | 0.819 mL | 1.0238 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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