Allantoin 97-59-6 standard supplier in China
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
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We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
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General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging:1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition:Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Cas No. | 97-59-6 | SDF | |
PubChem ID | 204 | Appearance | White powder |
Formula | C4H6N4O3 | M.Wt | 158.1 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Synonyms | 5-Ureidohydantoin | ||
Solubility | DMSO : 6 mg/mL (37.95 mM; Need ultrasonic and warming) | ||
Chemical Name | (2,5-dioxoimidazolidin-4-yl)urea | ||
SMILES | C1(C(=O)NC(=O)N1)NC(=O)N | ||
Standard InChIKey | POJWUDADGALRAB-UHFFFAOYSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
The roots of Phytolacca acinosa
Description | Allantoin, as I-1R agonist, has the potential to develop as a new therapeutic agent for hypertension. Allantoin has memory-enhancing, anti-oxidative and anti-inflammatory activities; it can enhance the antifungal activity of Nanoencapsulation. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth. Allantoin mediates PI3K-Akt-GSK-3β signal pathway. |
Targets | PI3K | Akt | GSK-3 | Antifection | Imidazoline I-1 receptor |
In vitro |
Solid lipid nanoparticles containing copaiba oil and allantoin: development and role of nanoencapsulation on the antifungal activity.[Pubmed: 25980176] Pharmazie. 2015 Mar;70(3):155-64. The aim of this work was to develop solid lipid nanoparticles (SLN) containing copaiba oil with and without Allantoin (NCOA, NCO, respectively) and to evaluate their antifungal activity. |
In vivo |
Effects of allantoin on cognitive function and hippocampal neurogenesis.[Pubmed: 24296131] Food Chem Toxicol. 2014 Feb;64:210-6. Allantoin is contained in Nelumbo nucifera (lotus) and a well-known cosmetic ingredient reported to have anti-oxidative and anti-inflammatory activities. In the present study, we investigated whether Allantoin affects cognitive function in mice. |
Kinase Assay |
The purine metabolite allantoin enhances abiotic stress tolerance through synergistic activation of abscisic acid metabolism.[Pubmed: 24182190] Plant Cell Environ. 2014 Apr;37(4):1022-36. Purine catabolism is regarded as a housekeeping function that remobilizes nitrogen for plant growth and development. However, emerging evidence suggests that certain purine metabolites might contribute to stress protection of plants. |
Animal Research |
Antihypertensive action of allantoin in animals.[Pubmed: 24745022] Biomed Res Int. 2014;2014:690135. The agonists of imidazoline I-1 receptors (I-1R) are widely used to lower blood pressure. It has been indicated that guanidinium derivatives show an ability to activate imidazoline receptors. Also, Allantoin has a chemical stricture similar to guanidinium derivatives. |
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 6.3251 mL | 31.6256 mL | 63.2511 mL | 126.5022 mL | 158.1278 mL |
5 mM | 1.265 mL | 6.3251 mL | 12.6502 mL | 25.3004 mL | 31.6256 mL |
10 mM | 0.6325 mL | 3.1626 mL | 6.3251 mL | 12.6502 mL | 15.8128 mL |
50 mM | 0.1265 mL | 0.6325 mL | 1.265 mL | 2.53 mL | 3.1626 mL |
100 mM | 0.0633 mL | 0.3163 mL | 0.6325 mL | 1.265 mL | 1.5813 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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