Details:

Usages: 

Indications Baloxavixate is indicated for patients ≥12 years of age with acute uncomplicated influenza within 48 hours of onset of symptoms. Limitations of use should be noted: influenza viruses vary over time and there are factors such as virus type and subtype, and changes in viral resistance and virulence of the virus once they occur may undermine the clinical efficacy of antiviral drugs, and available information on the sensitivity of locally circulating virus strains to drugs should be considered when deciding whether to take basalovir. Japanese patent JP6212678 reported the synthesis method of baloxavixate, the use of 3, 4-difluorobenzoic acid as raw material under the action of LDA reaction with DMF to obtain 2-formyl-3, 4-difluorobenzoic acid, and then with phenylthiophenol to form thioacetal, then borane reduction and separation to obtain 2-phenylthiomethyl-3, 4-difluorobenzoic acid. Then PPA was closed to obtain 7, 8-difluorodibenzo [b,e] thiophene-11 (6H) -ketone, and finally the key thiophene fragment 7, 8-difluoro-6, 11-dihydrodibenzo [b,e] thiophene-11-ol was obtained under the reduction of sodium borohydride. 3-(benzyloxy) -4-oxo-4h-pyrano-2-carboxylic acid is esterified and reacts with tert-butyl hydrazyl formate to obtain 3-(benzyloxy)-1-((tert-butoxycarbonyl) amino) -4-oxo-1, 4-dihydropyridine-2-methyl formate hydrate, and then reacts with 2-(2, 2-dimethoxyethoxy) ethylamine. Again under the action of mesylate cyclization get 7 - (benzyl oxygen) - 3,4,12,12 a - 4 h - 1 h - [1, 4] oxazine and [3, 4 - c] pyridine and 4-trichlorobenzene [1] [2, 1 - f] triazine - 6, 8 - diketone hemihydrate, Then with (R) - tetrahydrofuran - 2 - formic acid condensation crystallization separation after take off to chiral auxiliary for key chiral mother ring molecules (R) - 7 - (benzyl oxygen) - 3,4,12,12 a - 4 h - 1 h - [1, 4] oxazine and [3, 4 - c] pyrazole Chemicalbook organism and 4-trichlorobenzene [1] [2, 1 - f] triazine - 6, 8 - Diketone. Then the key parent ring molecule was used to exchange with n-hexyl alcohol under Grignell reagent, and then docked with the key thiophene fragment 7, 8-difluoro-6, 11-dihydrodibenzo [b,e] thiophene-11-alcohol, and finally debutyl and condensation with methyl chloroformate to obtain the final product baloxavixolate. The anti-influenza virus drug baloxavixate is a precursor drug, which enters the body and hydrolyzes into the active substance baloxavir, exerting the activity of anti-influenza virus. Barloxavir is an anti-influenza drug with a novel mechanism of action, which inhibits cap-dependent endonuclease in influenza virus, thereby blocking the transcription of the virus's own mRNA. The half-life of barloxavir is about 80 hours, and only one dose is needed. Mechanism of action Baloxavixolate is a small molecule precursor drug, its mechanism of action is different from the existing antiviral therapy, it can selectively inhibit CAP-dependent endonuclease, can prevent polymerase function and influenza virus mRNA replication. Existing anti-influenza drugs work by targeting neuraminidase. Compared to these drugs, Barloxavir targets an earlier stage of the viral replication cycle. Indications baloxavirmarboxil is a selective inhibitor of influenza virus CAP-dependent endonuclease. The drug has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents. Baloxavixolate, approved by the FDA in 2018, is a new anti-influenza drug with a novel mechanism of action, which can selectively inhibit CAP-dependent endonucrenase and prevent polymerase function and influenza virus mRNA replication. Valoxavir was developed by Shionoyi Pharmaceuticals and has signed an agreement with Roche, including Roche subsidiary Genentech, to jointly develop and commercialize valoxavir globally, and Shionoyi/Roche is currently conducting influenza phase 3 clinical trials of valoxavir in China.

About Us:

Hebei Kunsui Technology Co., Ltd. specializes in exporting high quality Pharmaceutical raw materials, plant extract, pesticide raw materials  and Chemical raw materials.
Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection. We earned customer trust and created a good reputation during these years.

Packing & Shipping:

Packing&Delivery:
Packing and Storage: Packed in double plastic bags inside, outside with 25kg Fiber Drum.
Drum Size: 40cm*40cm*50mm, 25KG/drum Nt.;27.5Kg/drum.Gt. Store in a well-closed container away from moisture.
Shelf Life: 2 years if sealed and store away from direct sun light.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.
Delivery time: Around 3 workdays after your payment.
Payments:We accept BTC//USDT/Bank transfer.

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 
  2. Shipping details & shipping documents will be provided and sent by email. 
  3. We keep tracking the shippment until clients well received. 
  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

FAQ:

Q: Is there a discount.

Yes, for larger quantity, we always support with better price.

Q2: Can I have free samples

Yes, we can supply the free 10-20g sample except high value products, but the shipping cost be paid by you. Generally USD45 for sample fee.

Q3: How do I pay the sample fee

Paypal,,T/T or just provide your courier's account number, we prefer FEDEX.

Q4: How do you treat quality complaint

If quality problem caused by us after Third Party Test, we will send you free goods for replacement or refund your payment.

Q5:What's your MOQ and lead time

Generally MOQ is 1kg, some low value products, MOQ is 25kg and lead time is within 4-5 workdays upon your payment.

Q6: Which products you can export

We are mainly exporting herbal extracts, amino acids, vitamins, cosmetics and APIs.

Q7: Which documents you can provide

Usually, we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your
markets have any special requirements, let us know.