Factory price Cetrimide CAS 8044-71-1 in stock

Details:

Factory price Cetrimide CAS 8044-71-1 in stock

Details

Cetrimide Basic information
Product Name:    Cetrimide
Synonyms:    TRIMETHYLMYRISTYLAMMONIUM BROMIDE;TRIMETHYL-TETRADECYLAMMONIUM BROMIDE;TTAB;N-TETRADECYL-N,N,N-TRIMETHYLAMMONIUM BROMIDE;(N-TETRADECYL)TRIMETHYLAMMONIUM BROMIDE;cetavlon;cetraol;lissolaminev
CAS:    8044-71-1
MF:    C17H38BrN
MW:    336.39
EINECS:    617-073-5
Product Categories:    
Mol File:    8044-71-1.mol
Cetrimide Structure
Cetrimide Chemical Properties
Melting point     245-250 °C(lit.)
solubility     H2O: 10 % (w/v)
CAS DataBase Reference    8044-71-1(CAS DataBase Reference)
Safety Information
Hazard Codes     C
Risk Statements     34-20/21/22
Safety Statements     26-36/37/39-45-28
RIDADR     UN 3263 8/PG 2
WGK Germany     3
RTECS     BS5776000
F     3
HS Code     29181100
MSDS Information
Provider    Language
ACROS    English
SigmaAldrich    English
ALFA    English
Cetrimide Usage And Synthesis
Chemical Properties    White or almost white, voluminous, free-flowing powder.
Chemical Properties    Cetrimide is a white to creamy white, free-flowing powder, with a faint but characteristic odor and a bitter, soapy taste.
Uses    antiinfectives
Production Methods    Cetrimide is prepared by the condensation of suitable alkyl bromides and trimethylamine.
Definition    ChEBI: Cetrimide is an organic molecular entity.
Pharmaceutical Applications    Cetrimide is a quaternary ammonium compound that is used in cosmetics and pharmaceutical formulations as an antimicrobial preservative. It may also be used as a cationic surfactant. In eye-drops, it is used as a preservative at a concentration of 0.005% w/v. Therapeutically, cetrimide is used in relatively high concentrations, generally as 0.1–1.0% w/v aqueous solutions, cream or spray as a topical antiseptic for skin, burns, and wounds.(1) Solutions containing up to 10% w/v cetrimide are used as shampoos to remove the scales in seborrheic dermatitis. Cetrimide is also used as a cleanser and disinfectant for hard contact lenses, although it should not be used on soft lenses; as an ingredient of cetrimide emulsifying wax, and in o/w creams (e.g. cetrimide cream).
Safety    Most adverse effects reported relate to the therapeutic use of cetrimide. If ingested orally, cetrimide and other quaternary ammonium compounds can cause nausea, vomiting, muscle paralysis, CNS depression, and hypotension; concentrated solutions may cause esophageal damage and necrosis. The fatal oral human dose is estimated to be 1.0–3.0 g.
At the concentrations used topically, solutions do not generally cause irritation, although concentrated solutions have occasionally been reported to cause burns. Cases of hypersensitivity have been reported following repeated application.
Adverse effects that have been reported following irrigation of hydatid cysts with cetrimide solution include chemical peritonitis, methemoglobinemia with cyanosis, and metabolic disorders.
storage    Cetrimide is chemically stable in the dry state, and also in aqueous solution at ambient temperatures. Aqueous solutions may be sterilized by autoclaving. Water containing metal ions and organic matter may reduce the antimicrobial activity of cetrimide.
The bulk material should be stored in a well-closed container in a cool, dry place.
Incompatibilities    Incompatible with soaps, anionic surfactants, high concentrations of nonionic surfactants, bentonite, iodine, phenylmercuric nitrate, alkali hydroxides, and acid dyes. Aqueous solutions react with metals.
Regulatory Status    Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Cetrimide is on the list of ‘Existing Active Substances’ on the market in the Europe, and is registered according to REACH regulation. Cetrimide is not present in any approved product in the USA.

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