Pharmaceutical Noopept GVS-111 Powder CAS 157115-85-0

Details:

Usages: 

Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action [2].in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions [4]. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) [5].Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity [6]. Clinical trial: Discontinued

About Us:

Hebei Kunsui Technology Co., Ltd. specializes in exporting high quality Pharmaceutical raw materials, plant extract, pesticide raw materials  and Chemical raw materials.
Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection. We earned customer trust and created a good reputation during these years.

Packing & Shipping:

Packing&Delivery:
Packing and Storage: Packed in double plastic bags inside, outside with 25kg Fiber Drum.
Drum Size: 40cm*40cm*50mm, 25KG/drum Nt.;27.5Kg/drum.Gt. Store in a well-closed container away from moisture.
Shelf Life: 2 years if sealed and store away from direct sun light.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.
Delivery time: Around 3 workdays after your payment.
Payments:We accept BTC//USDT/Bank transfer.

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 
  2. Shipping details & shipping documents will be provided and sent by email. 
  3. We keep tracking the shippment until clients well received. 
  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

FAQ:

Q: Is there a discount.

Yes, for larger quantity, we always support with better price.

Q2: Can I have free samples

Yes, we can supply the free 10-20g sample except high value products, but the shipping cost be paid by you. Generally USD45 for sample fee.

Q3: How do I pay the sample fee

Paypal,,T/T or just provide your courier's account number, we prefer FEDEX.

Q4: How do you treat quality complaint

If quality problem caused by us after Third Party Test, we will send you free goods for replacement or refund your payment.

Q5:What's your MOQ and lead time

Generally MOQ is 1kg, some low value products, MOQ is 25kg and lead time is within 4-5 workdays upon your payment.

Q6: Which products you can export

We are mainly exporting herbal extracts, amino acids, vitamins, cosmetics and APIs.

Q7: Which documents you can provide

Usually, we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your
markets have any special requirements, let us know.