Benfotiamine

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Benfotiamine Powder 98% 22457-89-2

Benfotiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect. Benfotiamine is primarily marketed as an antioxidant dietary supplement.

Benfotiamine: N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-S-benzoate dihydrogen phosphate

Molecular Formula:C19H23N4O6PS

Molecular Weight:466.45

CAS No.: 22457-89-2

EINECS:245-013-4

Appearance: White crystalline powder

Solubility: insoluble in water

Packing: 25kg/Fibre drum;

Storage:Avoid light, and preserved hermetically.

 

 

test items	specification	test results
appearance	white or almost white crystalline powder	white crystalline powder
loss on drying	≦0.5%	0.34%
melting point	139-141 °c	139-140 °c
(hplc)assay	97-103.0%	99.08%
free acid	0.5%max	0.31%
conclusion	the aboye product conforms analysis standard	conform

 

 

  

Benfotiamine is useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy however "Most of the effects attributed to benfotiamine are extrapolated from in vitro and animal studies. Unfortunately apparent evidences from human studies are scarce and especially endpoint studies are missing. Therefore additional clinical studies are mandatory to explore the therapeutic potential of benfotiamine in both diabetic and non-diabetic pathological conditions".

 

It is thought that treatment with benfotiamine leads to increased intracellularthiamine diphosphate levels, a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.

 

1. Benfotiamine is used for the prevention and treatment of vitamin B1 deficiency;

2. For vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.);

3. Benfotiamine is used in the treatment of non alcoholic wernicke encephalopathy;

4. To treat beriberi;

5. Used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as: neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.

 

1. Air Courier Express Door to Door Service （DHL / TNT / FEDEX / UPS / EMS）

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Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

 

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