Top Quality Natural Ceramides/Rice bran extract

Superiority:

Ceramide 3

CAS: 100403-19-8

Molecular Formula: C24H47NO3

1. Home
2. Product Category
3. Daily chemical industry
4. 100403-19-8

100403-19-8 - Names and Identifiers

100403-19-8 - Physico-chemical Properties

100403-19-8 - Introduction

ceramide (Ceramide) is a kind of phospholipid with ceramide as its skeleton, mainly including ceramide phosphocholine and ceramide phosphoethanolamine. Phospholipid is the main component of cell membrane. 40% ~ 50% of sebum in stratum corneum is composed of ceramide. Ceramide is the main part of intercellular matrix and plays an important role in maintaining the balance of water in stratum corneum. Ceramide has a strong ability to associate water molecules. It maintains skin moisture by forming a network in the stratum corneum. Therefore, ceramide has the effect of maintaining skin moisture.

Ceramide is the latest generation of humectant developed in recent years. It is a water-soluble lipid substance. It has a similar structure to the material that constitutes the stratum corneum of the skin. It can quickly penetrate into the skin and combine with the water in the stratum corneum to form a network structure that locks moisture.
Ceramide is the main component (>50%) of the intercellular lipid body of the stratum corneum that exists on the outermost side of the human skin. It plays an important role in preventing water dissipation and protecting external stimuli. It is responsible for protecting the skin and moisturizing, Moisturizing function. There are also many research reports that the use of ceramide-containing topical ointment products can achieve the purpose of preventing allergic skin diseases and inhibiting melanin brown spots.

external effects

The most widely known role of ceramide is to form a waterproof barrier on the skin. And combined with other lipids in a certain proportion can strengthen the barrier effect of ceramide. The best proportion is 50% ceramide, 25% cholesterol and 15% free fatty acids. This "transparent layered structure" mixture has a unique moisturizing function. Therefore, there is a mechanism that can explain the maintenance effect of ceramide.

the effect of ceramide on skin

1. moisturizing effect: ceramide is the main component of the skin's stratum corneum lipid, which can help repair the skin barrier and make the skin soft and shiny. But with age, ceramide gradually decreases, and the skin becomes dull and dry without it.

2. barrier function: ceramide in the skin can resist external stimulation if it is sufficient, but if it is missing or not, the skin will lose its natural protective function and have no defense ability to all external physical and biological injuries. For example, skin exposure to the sun is more prone to sunburn, cold weather and red and so on.

application

1. Anti-tumor

The pathogenesis of many tumors is related to the anti-apoptosis of cells. Therefore, the treatment of tumors is mainly to induce apoptosis. Traditional tumor treatment mainly relies on drug chemotherapy to induce apoptosis. Ceramide is different from general drugs in treating tumors. It can directly act on the apoptosis signal transduction pathway to cause apoptosis. Therefore, ceramide has opened up a new therapeutic scheme for anti-tumor. Ceramide is divided into endogenous ceramide and exogenous ceramide. In the process of treating tumors, the concentration of intracellular ceramide can be increased by directly adding exogenous ceramide or promoting the synthesis of endogenous ceramide, inducing apoptosis, and achieving the purpose of treating tumors. When cells are stimulated by various external conditions, endogenous ceramide begins to synthesize, which promotes the increase of intracellular ceramide concentration and may induce a series of physiological and pathological reactions such as apoptosis. Therefore, ceramide is considered to be a lipid that can inhibit tumor cells.

2. prevention and treatment of cardiovascular diseases

Vascular endothelial cells are the first barrier of the cardiovascular system. The integrity and endocrine function of vascular endothelial cells are related to whether the function of the cardiovascular system is normal. When the body is in a state of disease, the expression of a large number of inflammatory factors in the body will increase sharply. Overexpression of inflammatory factors will affect the integrity and endocrine function of endothelial cells, and in severe cases, it may even lead to endothelial cell apoptosis. Ceramide plays a significant role in inducing endothelial cell apoptosis. It can be seen that ceramide plays a very important role in regulating the integrity of endothelial cells and endocrine function. Ceramide induces apoptosis of vascular endothelial cells through Fas, which plays a very important role in studying the mechanism of ceramide-induced apoptosis of vascular endothelial cells.

3. Anti-inflammatory

TNF (tumor necrosis factor) is a positive regulator of inflammation. TNF can directly activate neutrophils. In recent years, data show that increasing the amount of intracellular ceramide can increase the amount of TNF in the body, thus triggering a variety of cell apoptosis. The effect of ceramide on TNF, a positive regulator of inflammation, indicates that ceramide has anti-inflammatory effect.

3. anti-allergic effect: this is a good news for children's shoes with thin skin. ceramide can help the stratum corneum thicken, improve the tolerance of the whole skin, protect the invasion of harmful substances from the outside world, avoid sensitive occurrence, and repair red blood streaks.

4. in addition, ceramide has very good anti-aging and auxiliary whitening and antioxidant effects.