Factory Supply YDL223C HBT1 99%

Details:

HBT1 binds to the ligand-binding domain of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) in a glutamate-dependent manner. This means that HBT1 is a molecule that can only bind to specific sites on the AMPA-R protein when glutamate is present, and that this binding helps regulate the protein's activity.  AMPA receptors are expressed throughout the central nervous system and play important roles in neuronal communication, sensory processing, and learning, memory, and synaptic plasticity.  AMPA receptors are major contributors to excitatory neurotransmission, mediate rapid, rapid desensitized excitation of many synapses, and are involved in early responses of synaptic regions to glutamate.  AMPA receptors are often coexpressed with NMDA receptors at synapses, and together they promote synaptic plasticity processes involved in learning, memory, excitotoxicity, and neuroprotection. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that plays an important role in the maintenance and expansion of neurons, and has potent and numerous effects on the proliferation, differentiation, survival and death of neuronal and non-neuronal cells, Acts as a neurotransmitter modulator and contributes to neuronal plasticity for learning and memory. It is therefore essential to the health and well-being of the nervous system.  An increase in BDNF may prove helpful in the treatment and prevention of many diseases.

 HBT1 is a novel AMPA receptor enhancer with lower agonism compared with LY451395 and OXP1, it induces the production of brain-derived neurotrophic factor (BDNF), and it shows little effect in primary neurons Agitation.  HBT1 binds to the ligand-binding domain of AMPA-R in a glutamate-dependent manner. Together, they promote synaptic plasticity processes involved in learning, memory, excitability and neuroprotection. It can improve the cognitive ability and memory of the brain, and enhance people's learning ability.