35084-48-1 Factory Supply 1-(1-Adamantylcarbonyl) proline (ACA)

Details:

1-(1-Adamantylcarbonyl) proline is a phenylalanine derivative, also known as adamantylproline or Ad-Pro. It is mainly used as a catalyst or chiral resolution reagent in organic synthesis.

Studies have shown that 1-(1-Adamantylcarbonyl) proline can catalyze asymmetric nucleophilic addition reactions, such as the reaction between aldehydes and alkylene azides, the reactions between aldehydes and sulfuryl folate, the reactions between aldehydes and nitromethane, etc. Among these reactions, this catalyst has the strongest addition activity to alkylene azides.

 1-(1-Adamantylcarbonyl) proline can also catalyze asymmetric amination reactions.  1-(1-Adamantylcarbonyl) proline can also be used as a chiral catalyst to catalyze asymmetric alcoholylation . For example, it can react alcohols with aldehydes or ketones to give the corresponding aldol or hydroxyketone products.  

1-(1-Adamantylcarbonyl) proline, as a chiral organic compound, has excellent catalytic activity. Due to its unique chiral properties, it is widely used in chiral organic synthesis, including asymmetric nucleophilic addition reactions, amination reactions, alcoholization reactions, etc.

1-(Adamantane-1-carbonyl)-pyrrolidine-2-carboxylic acid is a nitrogen-containing organic substance, white or off-white powder, used as intermediate or in medicine used to strengthen the brain, promote intelligence, refresh, and promote the development of damaged brain neurons.

 (1) 1-(1-Adamantylcarbonyl) proline is white or off-white powder with good solubility. It has low solubility in water, but often has good solubility in organic solvents. It is a stable compound that can be stored for a long time at room temperature.

 (2) 1-(1-Adamantylcarbonyl) proline is a chiral molecule with two enantiomers. Its chiral nature makes it widely used in chiral synthesis. Usually, only one chiral isomer should be used because of its good chiral induction.

 (3) 1-(1-Adamantylcarbonyl) proline is an effective chiral organocatalyst that can catalyze a variety of organic reactions without the need for metals. It can also interact with substrate molecules by forming hydrogen bonds or ion pairing to improve reaction efficiency and selectivity.

 (4) 1-(1-Adamantylcarbonyl) proline is mainly used in chiral organic synthesis and catalytic reactions. It can be used as chiral resolution reagent, chiral catalyst, chiral inducer, etc.