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Ajuga extract turkesterone 41451-87-0
CAS: 41451-87-0
Molecular Formula: C27H44O8
Molecular Formula | C27H44O8 |
Molar Mass | 496.63 |
Density | 1.33 |
Melting Point | 166-170°C |
Boling Point | 740.1±60.0 °C(Predicted) |
Specific Rotation(α) | +52 (c, 1.46 in MeOH) |
Flash Point | 415.3°C |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Vapor Presure | 2.79E-25mmHg at 25°C |
Appearance | Powder |
Color | Off-White to Pale Yellow |
pKa | 13.84±0.70(Predicted) |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Refractive Index | 1.609 |
MDL | MFCD04307740 |
In vitro study | The ability of Turkesterone to displace [ 3 H]ponA from in vitro-expressed DmEcR/DmUSP receptor complex is assessed. The EC 50 is 0.8 μM in the B II bioassay, K i value is 90 nM in the receptor assay. |
effect | dew grass (CyanotisarachnoideaC.B.Clarke), also known as pearl dew grass, chicken crown ginseng, etc., is a perennial herb of the genus Lanergrass of the Duckweed family. It is widely distributed in Yunnan Province. It has the effects of replenishing deficiency, dehumidification, relaxing muscles and activating collaterals. Tukesterone was isolated from this plant for the first time. |
preparation | dew grass (2.5kg) is heated and refluxed with 75% ethanol to recover ethanol to obtain concentrated solution. Extraction with ethyl acetate and n-butanol; Take the ethyl acetate extract, conduct Al2O3 (neutral) column chromatography, elute with chloroform-methanol gradient, chloroform-methanol (4:1) elution part is recrystallized with ethyl acetate-methanol to obtain compound 3(200mg); The 3: 1 elution part is prepared by thin layer chromatography (stationary phase: silica gel GF254; Mobile phase: chloroform-methanol = 5: 1) to obtain compound 1(10mg); The methanol elution part was separated by preparative high performance liquid chromatography (ODS, methanol/water = 31: 69,242nm detection) to obtain tukesterone (5mg). |
Biological activity | Turkesterone isolated from Ajuga turkestanica, Turkesterone is an effective ecdysone used as ecdysteroid receptor (EcR) agonist in some insect systems. |
target | Ecdysteroid receptor (EcR) |
Mol Download Chemical properties
CAS:
41451-87-0
MF:
C27H44O8
MW:
496.63
EINECS:
000-000-0
MDL No.:
MFCD04307740
Melting point:
166-170°C
Boiling point:
740.1±60.0 °C(Predicted)
Density
1.33
storage temp.
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility
DMSO (Slightly), Methanol (Slightly)
pka
13.84±0.70(Predicted)
form
Solid
color
Off-White to Pale Yellow
Water Solubility
insoluble in water
Stability:
Hygroscopic
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