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5-hydroxytryptophan 56-69-9 5-htp
DL-5-Hydroxytryptophan
CAS: 56-69-9;114-03-4
Molecular Formula: C11H12N2O3
Name | DL-5-Hydroxytryptophan |
Synonyms | 5-HTP DL-5-HTP H-Trp(5-OH)-OH HYDROXYTRYPTOPHAN 5-hydroxytrytophan 5-hydroxytryptophan DL-5-Hydroxytryptophan 5-hydroxy-D-tryptophan DL-5-HYDROXYTRYPTOPHAN 5-HYDROXY-DL-TRYPTOPHAN 5-Hydroxy-DL-tryptophan 5-Hydroxytryptophan(5-HTP) 5-HTP (Griffonia Seeds P.E.) 5-hydroxy-dl-tryptophan crystalline DL-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID DL-2-Amino-3-[3-(5-hydroxyindole)]propionic acid 2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid DL-2-Amino-3-(5-hydroxyindolyl)propionic acid, DL-5-HTP |
CAS | 56-69-9 114-03-4 |
EINECS | 200-284-8 |
InChI | InChI=1/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 |
InChIKey | LDCYZAJDBXYCGN-UHFFFAOYSA-N |
Molecular Formula | C11H12N2O3 |
Molar Mass | 220.22 |
Density | 1.484 |
Melting Point | 298-300°C |
Boling Point | 361.16°C (rough estimate) |
Specific Rotation(α) | -30.9~-34.7° |
Flash Point | 268.7°C |
Water Solubility | Soluble in water (4 mg/ml at 25°C), methanol. |
Solubility | Soluble in water |
Vapor Presure | 1.15E-11mmHg at 25°C |
Appearance | White powder |
Color | Off-White to Pale Beige |
Merck | 14,4847 |
BRN | 88199 |
pKa | 2.22±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.5200 (estimate) |
MDL | MFCD00005651 |
Physical and Chemical Properties | Light gray powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Africa Ghana seed. |
Use | Used as a Biochemical reagent |
In vitro study | 5-Hydroxytryptophan (5-HTP) is an intermediate in the biosynthesis of serotonin by the essential amino acid L-tryptophan (LT). It is able to easily cross the blood-brain barrier and effectively increases serotonin synthesis in the central nervous system (CNS). 5-HTP administration has been shown to be effective in treating a variety of conditions, including depression, fibromyalgia, obesity due to overeating, chronic headaches, and insomnia. Clinical evidence suggests that 5-Hydroxytryptophan provides better relief of depression than placebo. |
In vivo study | LD50: Mouse 1800 mg/kg (I. g.); Rat 300 mg/kg (I. g.) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
properties | light gray-white fine powder with slight gas and slightly salty taste. |
mechanism of action | 5-hydroxytryptophan is the precursor of human serotonin, can help the body balance this hormone to control the body's mood, improve sleep quality, and can effectively control appetite, improve the sensitivity of the satiety center, in the process of weight loss diet control, reduce hunger, make the weight loss process easier and easier to achieve. |
biological activity | 5-hydroxytrophophan (5-HTP, NSC-92523), in the presence of Vitamin B6, the enzyme aromatic-L-amino acid decarboxylase is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT). |
Use | use as a Biochemical reagent 1. Anti-depression: 5-HTP is a metabolite of the amino acid tryptophan, it is the precursor of human serotonin and is used to synthesize serotonin (an important substance that plays a role in the function of common nerves and brain). Helps with normal nerve material and brain function and can treat depression. 2, relieve stress and improve sleep: can help the body balance this hormone to control the body's mood, improve sleep quality, can effectively inhibit pain, thus 5-hydroxytryptophan was also used to treat Sleep Initiation and Maintenance Disorders. |
Mol Download Chemical properties
CAS:
56-69-9
MF:
C11H12N2O3
MW:
220.22
EINECS:
200-284-8
MDL No.:
MFCD00005651
Melting point:
298-300°C
Boiling point:
361.16°C (rough estimate)
Density
1.484
refractive index
1.5200 (estimate)
storage temp.
Keep in dark place,Sealed in dry,Room Temperature
solubility
DMSO (Slightly), Methanol (Slightly)
pka
2.22±0.10(Predicted)
form
solid
color
Off-White to Pale Beige
Water Solubility
Soluble in water (4 mg/ml at 25°C), methanol.
Merck
14,4847
BRN
88199
InChIKey
LDCYZAJDBXYCGN-UHFFFAOYSA-N
LogP
-0.292 (est)
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