Top Quality Natural vinpocetine

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1 Kilogram	FOB Price:USD 35.0000 -49.0000

1 Kilogram

FOB Price:USD 35.0000 -49.0000

Min.Order :1 Kilogram
Purity: 99%
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Keywords

vinpocetine 42971-09-5 vinpocetine powder

Quick Details

Appearance:white powder
Application:Pharmaceutical;Food Preservative;Cosmetics;Food
PackAge:1kg/bag,5kg/bag,25kg/drum
ProductionCapacity:5000|Kilogram|Month
Storage:in a cool&dry place
Transportation:By air,By Sea

Superiority:

Vinpocetine

CAS: 42971-09-5;80038-06-8

Molecular Formula: C22H26N2O2

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42971-09-5

42971-09-5 - Names and Identifiers

Name	Vinpocetine
Synonyms	TCV-3B RGH 4405 RGH-4405 CAVINTON Cavinton AY 27,255 VINPOCETIN Vinpocetine BRN 0900803 Vinpocetinum EBURNAMENINE UNII-543512OBTC Apovincaminate d'ethyle Ethyl (+)-apovincaminate Vinpocetinum [INN-Latin] Ethyl apovincamin-22-oate ETHYL APOVINCAMIN-22-OATE Ethyl (+)-cis-apovincaminate Apovincaminic acid ethyl ester Apovincaminate d'ethyle [French] ethyl eburnamenine-14-carboxylate (+)-Apovincaminic acid ethyl ester cis-Apovincaminic acid ethyl ester 3A,16A-APOVINCAMINIC ACID ETHYL ESTER (+)-cis-Apovincaminic acid ethyl ester EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER 3-alpha,16-alpha-Apovincaminic acid ethyl ester ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate (3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER (3alpha,16alpha)-14-(ethoxycarbonyl)eburnamenin-4-ium Eburnamenine-14-carboxylic acid, ethyl ester, (3alpha,16alpha)- Eburnamenine-14-carboxylic acid, ethyl ester, (3-alpha,16-alpha)-
CAS	42971-09-5 80038-06-8
EINECS	256-028-0
InChI	InChI=1/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/p+1/t20-,22+/m1/s1
InChIKey	DDNCQMVWWZOMLN-IRLDBZIGSA-N

42971-09-5 - Physico-chemical Properties

Molecular Formula	C22H26N2O2
Molar Mass	350.46
Density	1.1260 (rough estimate)
Melting Point	147-153 °C dec.
Boling Point	484.44°C (rough estimate)
Specific Rotation(α)	D20 +114° (c = 1 in pyridine)
Flash Point	207.506°C
Solubility	Soluble in chloroform or 96% ethanol, almost insoluble in water.
Vapor Presure	0mmHg at 25°C
Appearance	White fine powder
Color	white
Maximum wavelength(λmax)	['315nm(EtOH)(lit.)']
Merck	14,9991
pKa	7.87±0.60(Predicted)
Storage Condition	Sealed in dry,2-8°C
Stability	Photosensitive
Sensitive	Sensitive to light
Refractive Index	1.6500 (estimate)
MDL	MFCD00211233
Physical and Chemical Properties	White crystalline powder, odorless and tasteless. Soluble in chloroform or 96% ethanol, a few insoluble in water. Melting point 147-153 °c (decomposition). [Α] D20 +114 °(C = 1, pyridine). UV maximum absorption (96% ethanol):229,275,315nm (h28200, 12000,7100). Acute toxicity LD50 mice, rats (mg/kg):534,503 oral; 240,133.8 intraperitoneal injection; 58.7,42.6 intravenous injection.
Use	Cerebrovascular medication

cerebral vasodilator	vinpocetine is a cerebral vasodilator, which has a stronger effect than vinblastamide and selectively increases cerebral blood flow; it can increase and Improve the supply of cerebral oxygen, promote metabolism, enhance the deformability of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and improve brain tissue metabolism. Mainly used to treat sequelae of cerebral infarction, sequelae of cerebral hemorrhage, cerebral arteriosclerosis, etc. It is also used to treat retinal vascular sclerosis and vasospasm, deafness and vertigo in the elderly. Vinpocetine is a semi-synthetic vincamine derivative. The effect is similar to that of vincamine, and it has a higher selective dilation effect on cerebral blood vessels. The pharmacological effects are as follows: ① Inhibit calcium-dependent phosphodiesterase activity, increase the cAMP content of relaxing vascular smooth muscle, thereby relaxing vascular smooth muscle and increasing cerebral blood flow. ②Enhance red blood cell deformability, reduce blood viscosity, inhibit platelet aggregation, thereby improving blood fluidity and microcirculation. (3) Promote the uptake of glucose in brain tissue and promote the metabolic transformation of monoamines in brain. ④ During cerebral ischemia, it can inhibit the increase of lactic acid in the brain, increase the content of ATP, inhibit the production of lipid peroxides in the brain, and delay the occurrence time of cerebral ischemia spasm, so it can improve brain metabolism and protect brain function. Figure 1 is a vinpocetine structure.
Application	Vinpocetine is often used for cerebral arteriosclerosis, cerebral ischemia and hemorrhagic stroke sequelae, transient ischemic attack and other cerebral circulation disorders It is also used to treat symptoms induced by cerebral circulation disorders, such as aphasia, inability to use, poor memory, cognitive dysfunction, dizziness, headache and other brain vestibular problems, etc, it is a first-line drug widely used in the treatment and prevention of ischemic cerebrovascular diseases.
Pharmacokinetics	Vinpocetine has high fat solubility, is easy to be absorbed by tissues, and is widely distributed. It can pass through the blood-brain barrier and is mainly metabolized in the liver. It is apovincamine, which is excreted by the kidney.
Efficacy and Function	Vinpocetine, also known as vinpac ethyl ester, Kangweinao, Karan, and ethyl apvinamide, is a natural medicine extracted from vinca vinca and belongs to indole alkaloids. Now it has been artificially synthesized. Its pharmacological effects: increase cerebral blood flow, increase the effect of cyclic guanosine by inhibiting Ca2 +-dependent phosphodiesterase activity, selectively relax smooth muscle, and increase cerebrovascular blood flow; improve blood fluidity and microcirculation, that is, by Enhancing the deformability of red blood cells, reducing blood viscosity, and inhibiting platelet aggregation to play this role; improving brain metabolism: increasing cerebral oxygen supply, promoting brain tissue uptake of glucose, and promoting brain monoamine metabolism and transformation, inhibit the increase of lactic acid metabolism and ATP content in ischemic brain, increase the oxygen dissociation degree of hemoglobin, increase the anti-hypoxia ability of brain, inhibit the occurrence of ischemic cerebral vasospasm and the production of lipid peroxides. It is well absorbed by oral administration, reaching a peak value at 1h, and metabolized into apovinylic acid in vivo. The plasma elimination half-life is about 1 hour. Continuous administration for 4 weeks, no accumulation in the body. Clinically used for clinical manifestations such as cerebral infarction sequelae, cerebral hemorrhage sequelae, cerebral arteriosclerosis, cerebral vasospasm, vertigo, tinnitus, headache, dizziness, numbness of the limbs, incontinence, and depression, Anxiety, sleep disorders and other mental symptoms. Clinical experience shows that it is effective regardless of the length of the disease and whether the symptoms are fixed.
indications	1. neurology department: various cerebrovascular diseases and their sequelae, etc. 2. Department of Cardiology: Coronary heart disease, arteriosclerosis and abnormal blood viscosity. 3. Ophthalmology: visual impairment caused by poor blood circulation in various fundus, etc. 4. otonasal nuclei: hearing impairment, tinnitus, vestibular dysfunction, etc. 5. Neurosurgery: Rehabilitation treatment of brain function after various craniocerebral operations.
preparation method	at present, there are two preparation methods of vinpocetine, one is to carry out total synthesis by chemical method, and the other is to extract vinpocetine from plants containing vinpocetine as raw material for semi-synthesis. In the chemical synthesis of vinpocetine, the construction of the fifth ring occupies a key position, and there are many methods reported in the literature, such as Oppoleor aldehyde method, trimethylchlorosilane method, etc.
adverse reactions	the nervous system can see head weight, dizziness, occasional drowsiness and numbness of lateral limbs, etc. The digestive system can see nausea, vomiting, loss of appetite, abdominal pain, diarrhea, etc. The circulatory system can see symptoms such as facial flushing and dizziness. Leukopenia can be seen in the blood system. Liver reaction showed that AST and ALT increased, rare alkaline phosphatase increased. Renal reaction shows that blood urea nitrogen increases. Sometimes allergic reactions such as rash, urticaria, pruritus, etc. may occur, and the drug should be stopped at this time. Occasionally, slight decrease in blood pressure, tachycardia, etc.
precautions	patients with intracranial hemorrhage and pregnant or lactating women are prohibited.
use	an alkaloid extracted from Apocynaceae, a derivative of vincamine (Vincamine). Selective inhibition of cerebral vascular smooth muscle calcium-dependent phosphodiesterase, cGMP increase, cerebral vascular expansion, and then increase cerebral blood flow, improve cerebral circulation, but has little effect on cardiovascular and blood pressure. Fast onset, good tolerance, small adverse reactions. Used for dizziness, headache, memory impairment, mobility disorders, aphasia, hypertensive encephalopathy, etc., and also used for mental or neurological symptoms caused by cerebral blood circulation disorders. Cerebrovascular medication. Ca2 + calmodulin-dependent type I phosphodiesterase (PDE1) inhibitor A selective PDE1 inhibitor, IC50:21 μM, is also a pressure sensitive sodium ion channel.

Details:

Vinpocetine

Mol Download Chemical properties

CAS:

42971-09-5

MF:

C22H26N2O2

MW:

350.46

EINECS:

256-028-0

MDL No.:

MFCD00211233

Properties

Melting point:

147-153 °C dec.

alpha

D20 +114° (c = 1 in pyridine)

Boiling point:

484.44°C (rough estimate)

Density

1.1260 (rough estimate)

refractive index

1.6500 (estimate)

storage temp.

Sealed in dry,2-8°C

solubility

DMSO: 5 mg/mL

pka

7.87±0.60(Predicted)

form

solid

color

white

optical activity

[α]/D 148.5±5.0°, c = 0.1 in chloroform

λmax

315nm(EtOH)(lit.)

Merck

14,9991

Stability:

Photosensitive

InChIKey

DDNCQMVWWZOMLN-IRLDBZIGSA-N

LogP

5.137 (est)

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