Top Quality Natural Colchicine

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1 Kilogram	FOB Price:USD 35.0000 -49.0000

1 Kilogram

FOB Price:USD 35.0000 -49.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T,Other

Keywords

Colchicine Colchisol natural ferulic acid

Quick Details

Appearance:white powder
Application:Pharmaceutical;Food Preservative;Cosmetics;Food
PackAge:1kg/bag,5kg/bag,25kg/drum
ProductionCapacity:5000|Kilogram|Month
Storage:in a cool&dry place
Transportation:By air,By Sea

Superiority:

Colchicine

CAS: 64-86-8

Molecular Formula: C22H25NO6

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64-86-8

64-86-8 - Names and Identifiers

Name	Colchicine
Synonyms	Colchicine len-7-yl)- Colchicine 64-86-8 Colchicine Acetamide 64-86-8 Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy- n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-acetamid N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide N1-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)- (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide N-((S)-1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL)-ACETAMIDE
CAS	64-86-8
EINECS	200-598-5
InChI	InChI=1/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChIKey	IAKHMKGGTNLKSZ-INIZCTEOSA-N

64-86-8 - Physico-chemical Properties

Molecular Formula	C22H25NO6
Molar Mass	399.44
Density	1.2770 (rough estimate)
Melting Point	150-160°C (dec.)(lit.)
Boling Point	522.37°C (rough estimate)
Specific Rotation(α)	-250 º (c=1, alcohol)
Flash Point	392.9°C
Water Solubility	45 g/L (20 ºC)
Solubility	Soluble in ethanol, chloroform
Vapor Presure	6.21E-21mmHg at 25°C
Appearance	White powder
Color	white to yellow with a green cast
Merck	14,2471
BRN	2228813
pKa	12.36(at 20℃)
Storage Condition	2-8°C
Stability	Stable. Light sensitive. Incompatible with strong oxidizing agents.
Sensitive	Light Sensitive
Refractive Index	1.5614 (estimate)
MDL	MFCD00078484
Physical and Chemical Properties	Light yellow crystal or crystalline powder, taste, taste bitter, see light discoloration. Mp157 ℃ (ethyl acetate recrystallization), specific rotation [α]17D-429 °(1.72%, water), -121 °(0.9%, chloroform), the maximum absorption wavelength in ethanol was 243nm and 350.5nm. This product is soluble in water, ethanol and chloroform, soluble in benzene and ether, insoluble in petroleum ether, 0.5% of this solution is weakly acidic. LD50 (mouse, abdominal cavity) 6.1 mg/kg.
Use	Anti-gout and anti-tumor drugs for the treatment of acute gout and cancer

alkaloid	colchicine, also known as colchicine, is an alkaloid extracted from the bulbs and seeds of the Liliaceae plant colchicine, it is found naturally in the Liliaceae plant jialanensis (0.11%) and Lijiang (0.1%). Light yellow needle-like crystals. It is slightly odorous and bitter. Melting point 157 ℃, soluble in cold water, alcohol, chloroform and formaldehyde, poor solubility in hot water, not soluble in benzene and ether, almost insoluble in petroleum ether, 0.5% solution pH 5.9, after hydrolysis by ammonia, the toxicity can be reduced. Colchicine has anti-mitotic and anti-tumor effects. In 1889, the effect of colchicine on mitosis was first discovered by an Italian scholar, Pernica, who described that the mitotic phase of the cells in the inner wall of the Dog stomach was suppressed by colchicine and the spindle was destroyed, paralysis of chromosome action, abnormal mitotic cells remain in a large number of metaphase. This abnormal division caused by colchicine is called colchicine mitosis (C-mitosis for short). Colchicine is one of the most widely used chemical agents in karyotype analysis and polyploid mutagenesis. The concentration of the aqueous solution is positively correlated with the efficacy of its action, and the higher the concentration, the stronger the effect. Various plants and different tissues respond differently to colchicine. In summary, the treatment time for young and rapidly dividing tissues (such as the embryo of germinating seeds) can be shorter and the concentration should be lower; Whereas the treatment time can be longer and the concentration should be higher. The effective concentration of colchicine treatment was 0.01~10 ~ 0.4%, and about 0.2% of the most widely used. For example, the concentration of 0.2 ~ 0.4% colchicine solution drops on the growth point of diploid watermelon seedlings, once a day, for 4 consecutive days, and shade to maintain humidity, can induce tetraploid watermelon. For cereal crops, such as rice, the robust seedlings with more than four true leaves can be cut at the root neck, and immersed in 0.025 ~ 0.05% colchicine solution without cutting the growing point, submerged incision, after 8 to 14 days (20 degrees C) can also be obtained tetraploid plants. At present, colchicine is widely used for chromosome doubling of haploid plants obtained from anther (powder) and ovary culture.
anti-gout drugs	colchicine has a good effect on acute gout, which can relieve pain quickly and prevent the onset of arthritis, its mechanism of action is related to inhibiting the proliferation and activity of leukocytes and affecting the release of lysosomes. The pharmacological effect of this product is to reduce the activity and phagocytosis of leukocytes in inflammatory tissues, reduce the inflammation caused by uric acid crystals, and thus play an anti-inflammatory, detumescence and analgesic effect, therefore, it has a selective anti-inflammatory effect on acute gouty arthritis. In addition, this product is also a kind of mitotic toxin, which has a strong effect of inhibiting cell division, so that the cell stops in the division phase, resulting in the death of tumor cells, so it can be used for cancer treatment. This product is easy to absorb after oral administration, 30% is combined with plasma protein, the peak time of blood drug concentration is 0.5~2 hours after oral administration, and the peak concentration of 2mg is about 2.2ng/ml, after 12 hours of acute gout administration, the drug effect can be sustained for 50 to 70 hours, and the drug concentration in the isolated neutrophils is higher than the plasma concentration and can be maintained for 10 days. Most of this product is metabolized by the liver, metabolites and prototype drugs are excreted by the bile, reabsorbed by the intestine, not absorbed by the intestine. The remaining about 10% ~ 20% by the kidney with urinary excretion. This product does not affect the formation, dissolution and excretion of uric acid salt, and thus has no effect of lowering blood uric acid. It is clinically used to treat acute attack of gouty arthritis, prevent acute attack of recurrent gouty arthritis, familial Mediterranean fever, leukemia, skin cancer, Hodgkin's disease, aplastic anemia, etc. Also used for breast cancer, lung cancer, esophageal cancer, cervical cancer, nasopharyngeal carcinoma, Hodgkin's disease, chronic myelogenous leukemia, skin cancer and other malignant diseases M stage cycle specific treatment.
adverse reactions	and dose size were significantly correlated. 1. Gastrointestinal reactions: Nausea, Abdominal Pain, Diarrhea, Vomit and loss of appetite for the common early adverse reactions, the incidence rate of up to 80%, severe cases can cause dehydration and electrolyte disorders and other performance, such as the reaction immediately discontinued. Long-term users may develop severe hemorrhagic gastroenteritis or malabsorption syndrome. 2. Blood system reaction: Long-term medication can cause agranulocytosis, thrombocytopenia, aplastic anemia, and sometimes life-threatening. 3. Other toxic reactions; Mainly for urethral irritation symptoms, such as frequency, urgency, dysuria, hematuria, Oliguria, and even renal failure. Stomach, pharynx or skin burning sensation, and Fever, bloody Diarrhea, mental changes, myasthenia gravis, respiratory depression and other symptoms. 4. Check hemogram, liver and kidney function during taking colchicine. Hematopoietic insufficiency, liver and kidney damage, severe heart disease and gastrointestinal disease patients should be used with caution. Contraindicated in pregnant women. 5. Muscle, peripheral neuropathy: proximal muscle weakness, and serum creatine kinase increased; Muscle damage in the peripheral nerve axonal polyneuropathy may occur at the same time, manifested as numbness, tingling and weakness; muscle neuropathy is rare, often in the prevention of gout and long-term users and mild renal insufficiency appear.
dosage and usage	tablet: 0.5mg per tablet; Injection: 1mg, 2mg. 1. For the treatment of acute gout: adult oral tablets, the first dose of 0.5~1mg, after every 1~2 hours to take 0.5~0.6mg, until the joint symptoms or gastrointestinal symptoms, that is, withdrawal. The general total dose of 4~10mg effective. Note that the earlier the drug is used in the acute phase, the better the effect is. If intravenous injection, the first dose of 1~2mg, with normal saline 20ml slow injection, time of not less than 5 minutes, if necessary, every 6~12 hours intravenous injection of 0.5~1mg, until effective, the total dose of 4~5mg/d. The effect of intravenous injection was better than that of oral administration, and the gastrointestinal reaction was significantly reduced. 2. For the prevention of acute gout: adult tablets 0.5~0.6mg each time, 2 times a day or intravenous injection of 1~2mg/d. 3. For the experimental diagnosis of gout: such as acute joint symptoms after medication relief, that is helpful to confirm the diagnosis.

Details:

Colchicine

Mol Download Chemical properties

CAS:

64-86-8

MF:

C22H25NO6

MW:

399.44

EINECS:

200-598-5

MDL No.:

MFCD00078484

Properties

Melting point:

150-160 °C (dec.)(lit.)

alpha

-250 º (c=1, alcohol)

Boiling point:

522.37°C (rough estimate)

Density

1.2770 (rough estimate)

refractive index

1.5614 (estimate)

storage temp.

2-8°C

solubility

H₂O: 10 mg/mL

pka

12.36(at 20℃)

form

powder

color

white to yellow with a green cast

Water Solubility

45 g/L (20 ºC)

Sensitive

Light Sensitive

Merck

14,2471

BRN

2228813

BCS Class

Stability:

Stable. Light sensitive. Incompatible with strong oxidizing agents.

InChIKey

IAKHMKGGTNLKSZ-INIZCTEOSA-N

LogP

1.300

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