Top Quality Natural...

Top Quality Natural Cinchonidine 98%
Top Quality Natural Cinchonidine 98%
Top Quality Natural Cinchonidine 98%
Top Quality Natural Cinchonidine 98%

Top Quality Natural Cinchonidine 98%

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 35.0000 -49.0000

  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : T/T,Other

Keywords

Cinchonidine 485-71-2 Cinchonidine factory

Quick Details

  • Appearance:white powder
  • Application:Pharmaceutical;Food Preservative;Cosmetics;Food
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:5000|Kilogram|Month
  • Storage:in a cool&dry place
  • Transportation:By air,By Sea

Superiority:

Cinchonidine

CAS: 485-71-2

Molecular Formula: C19H22N2O

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485-71-2 - Names and Identifiers

Name Cinchonidine
Synonyms Cinchonidine
Cinchovatine
L-Cinchonidine
Cinchonan-9-ol
alpha-Quinidine
(9R)-cinchonan-9-ol
(8s,9r)-cinchonidine
(9R)-cinchonan-1-ium-9-ol
(8alpha,9R)-Cinchonan-9-ol
(8-alpha,9r)-cinchonan-9-o
Cinchonidinederivedcatalyst
Cinchonan-9-ol, (8alpha,9R)-
(8alpha,9theta)-cinchonan-9-o
(8alpha,9R)-9-hydroxycinchonan-1-ium
(3alpha,9R)-9-hydroxycinchonan-1-ium
(4beta,8alpha,9R)-cinchonan-1-ium-9-ol
(3alpha,4beta,8alpha,9S)-cinchonan-9-ol
2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-
CAS 485-71-2
EINECS 207-622-3
InChI InChI=1/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/p+1/t13-,14+,18-,19-/m1/s1
InChIKey KMPWYEUPVWOPIM-NAHPKXJFSA-N

485-71-2 - Physico-chemical Properties

Molecular Formula C19H22N2O
Molar Mass 294.39
Density 1.0863 (rough estimate)
Melting Point 204-206°C(lit.)
Boling Point 436.16°C (rough estimate)
Specific Rotation(α) -115 º (c=1, EtOH)
Flash Point 234.723°C
Water Solubility Insoluble
Solubility 0.25g/l
Vapor Presure 0Pa at 25℃
Appearance Bright yellow crystal
Color White to cream
Merck 14,2286
BRN 89690
pKa 5.80, 10.03(at 25℃)
PH 9 (0.2g/l, H2O, 20℃)
Storage Condition Keep in dark place,Inert atmosphere,Room temperature
Stability Stable, but light-sensitive. Incompatible with strong oxidizing agents.
Sensitive Light Sensitive
Refractive Index -107.5 ° (C=1, EtOH)
MDL MFCD00006783
In vitro study Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with K i s of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively.

 

Introduction Cinconidine is a quinoline alkaloid, a kind of cinchona alkaloid, also known as cinchona nidin, which is the stereoisomer of cinchonine. White needle-like or prismatic crystals obtained from ether. Melting point 204~206 ℃, specific rotation -115 (ethanol, C = 1), refractive index -107.5 (ethanol, C = 1). Soluble in alcohol, ether, acetone, benzene and chloroform, almost insoluble in cold water.
application cinkonidine is an organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory organic synthesis process and chemical medicine research and development process.
Effect Like quinine, it has antimalarial effect. After quinine can be separated from cinchona bark extract, the mother liquor is treated with alkali to precipitate alkaloids, and tartaric acid is added to make it insoluble tartrate separated.
Structural characteristics Cinchona (such as quinine, quinidine, cinkonine, cinkonidine, etc.) is a kind of natural product of great significance found in cinchona bark about two centuries ago. In the early years, it was a specific drug for the treatment of malaria. In recent years, it has been used as the dominant framework of catalysts in asymmetric synthesis. From the perspective of biosynthesis, cinchona alkaloids are derived from monoterpene indole alkaloids.
Biological activity Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.
target ki: 330 μ m (dSERT), 4.2 μ m (hSERT), 36 μ m (hSERT i172m), 196 μ m (hSERT s438t), 15 μ m (hSERT y95f)

 

Details:

Cinchonidine

Mol Download Chemical properties

CAS:

485-71-2

MF:

C19H22N2O

MW:

294.39

EINECS:

207-622-3

MDL No.:

MFCD00006783

Properties

Melting point:

204-206 °C(lit.)

alpha 

-115 º (c=1, EtOH)

Boiling point:

436.16°C (rough estimate)

Density 

1.0863 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

-107.5 ° (C=1, EtOH)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

0.25g/l

pka

5.80, 10.03(at 25℃)

form 

Crystalline Powder

color 

White to cream

PH

9 (0.2g/l, H2O, 20℃)

optical activity

[α]23/D 109.2°, c = 1.5 in ethanol

Water Solubility 

Insoluble

Sensitive 

Light Sensitive

Merck 

14,2286

BRN 

89690

Stability:

Stable, but light-sensitive. Incompatible with strong oxidizing agents.

InChIKey

KMPWYEUPVWOPIM-NAHPKXJFSA-N

LogP

2.68 at 25℃


Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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