Top Quality Natural...

Top Quality Natural Kaempferol
Top Quality Natural Kaempferol

Top Quality Natural Kaempferol

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99%
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Keywords

Kaempferol 520-18-3 Kaempferol powder

Quick Details

  • Appearance:yellow powder
  • Application:Pharmaceutical;Food Preservative;Cosmetics;Food
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:5000|Kilogram|Month
  • Storage:in a cool&dry place
  • Transportation:By air,By Sea

Superiority:

Kaempferol

CAS: 520-18-3

Molecular Formula: C15H10O6

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520-18-3 - Names and Identifiers

Name Kaempferol
Synonyms c.i.75640
kampherol
campherol
kempferol
Kaempferol
kaempherol
C.I. 75640
indigoyellow
5,7,4'-trihydroxyflavonol
3,5,7,4-Tetrahydroxyflavone
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
CAS 520-18-3
EINECS 208-287-6
InChI InChI=1/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H
InChIKey IYRMWMYZSQPJKC-UHFFFAOYSA-N

520-18-3 - Physico-chemical Properties

Molecular Formula C15H10O6
Molar Mass 286.24
Density 1.2981 (rough estimate)
Melting Point 276°C
Boling Point 348.61°C (rough estimate)
Flash Point 240.7°C
Solubility Slightly soluble in water, soluble in hot ethanol, ether and alkali.
Vapor Presure 6.38E-16mmHg at 25°C
Appearance Yellow powder
Color yellow
Merck 14,5274
BRN 304401
pKa 6.34±0.40(Predicted)
Storage Condition 2-8°C
Stability Unstable in Solution
Refractive Index 1.4413 (estimate)
MDL MFCD00016938
Physical and Chemical Properties Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Kaempferia rhizome, Locust, tea, broccoli, grapefruit.

 

color index 75640
(IARC) carcinogen classification 3 (Vol. 31, Sup 7) 1987
overview flavone is a natural polyphenol compound, which exists in a large number of fruits and vegetables eaten by human daily. it has many biological activities such as antioxidant, anticancer and anti-inflammatory, and has always been a hot research topic at home and abroad. kaempferol (kaempferol) is a kind of flavonoid compound, also known as kaempferol -3, kaempferol, kaempferol, thyphene III, widely exists in fruits, vegetables and Chinese herbal medicine and other natural plants.
effect kaempferol has antioxidant, anti-inflammatory, anti-cancer, prevention and treatment of diabetes, atherosclerosis and osteoporosis, as well as protection of nerve, liver and myocardium, inhibition of protein kinase and other nutritional and health effects. As a health food and medicine, kaempferol has a very broad market.
preparation 1) hydrolysis to prepare hydroxyacetophenone intermediate 1.1) put 30g of dihydromyricetin with a content of more than 98% into the reactor, then add 400g of sodium hydroxide solution with a mass fraction of 15%, stir and mix evenly, raise the temperature and reflux, and carry out hydrolysis reaction; High performance liquid chromatography monitoring, with the hydroxyacetophenone intermediate no longer increasing as the reaction control end point, after 2 hours, stop the reaction. Cooling to 30 ℃, slowly dropping 50% hydrochloric acid solution into the reaction solution, adjusting pH to about 6.2, stirring for 2 hours, standing for 1 hour, filtering to obtain light yellow viscous solid. 1.2) 150g of 95% ethanol is added to the light yellow viscous solid obtained in step 1.1), heated and refluxed for 1h, then filtered to obtain a solid while hot, then 90g of 95% ethanol is added to the solid, heated and refluxed for 1h again, beaten to room temperature, let stand for 2h, then filtered and dried to obtain a light yellow solid, I .e. hydroxyacetophenone intermediate (2-hydroxy -1-(2,4, 6-trihydroxyphenyl) acetyl) 17.8g. 2) Catalytic closed-loop preparation of crude dihydrokaempferol 2.1) Put 17.8g of hydroxyacetophenone intermediate obtained by the reaction in step 1.2) into the reaction bottle, add DMF92g, and stir to completely dissolve the hydroxyacetophenone intermediate. 2.2) Add 3.55g of proline to the solution in step 2.1), raise the temperature to 65 ℃ and keep the temperature unchanged, dissolve 13.9g of p-hydroxybenzaldehyde with 20gDMF and slowly drop it into the reaction bottle for about 2 hours. After dropping, the temperature was raised to 70 ℃ for heat preservation, and the catalytic closed-loop reaction was carried out. High performance liquid chromatography monitoring was carried out. The dihydrokaempferol intermediate was no longer increased as the reaction control end point, and the reaction ended after about 7 hours. 2.3) The solution obtained in step 2.2) is reduced to room temperature, 350g of 5% glacial acetic acid solution is added, stirred for 2 hours, and solid is slowly precipitated. Filter, wash the filter cake with water until neutral and dry to obtain 27.6g of crude dihydrokaempferol. 3) Oxidation Preparation of kaempferol 27.6g of crude dihydrokaempferol obtained in step 2.3) is put into a reaction bottle, 275ml of 65% ethanol is added, stirred evenly, 6g of anhydrous potassium carbonate is added, oxygen is introduced, then the temperature is raised and refluxed, the oxidation reaction is carried out, high performance liquid chromatography monitoring is carried out, the reaction control endpoint is no longer increased with kaempferol, and the reaction is over after about 8 hours. Drop to room temperature and leave overnight, filter to obtain yellow solid, add 200g of water, filter after reflux for 2h, wash and dry the filter cake to obtain 22.3g of kaempferol with 98% content (HPLC).
traits kaempferol is brown to light yellow crystalline powder; The gas is slight and the taste is pungent.
pharmacological effects kaempferol has anti-cancer, anti-fertility, anti-epilepsy, anti-inflammatory, antioxidant, antispasmodic, anti-ulcer, choleretic diuretic, antitussive and other effects.
use an effective osteoclast bone resorption inhibitor.
It has anti-cancer, anti-fertility, anti-epilepsy, anti-inflammatory, antioxidant, antispasmodic, anti-ulcer, choleretic and diuretic, and cough.
a flavonol. It can restore the deformation of mouse fibroblasts treated with phorbol ester or v-H-ras-transformed NIH 3T3 cells. It can significantly induce nuclear DNA degradation, accompanied by lipid peroxidation. Inhibition of DNA reattachment catalyzed by topoisomerase I.
production method after the plant material is crushed, the plant material is extracted with water or ethanol; then polyamide (polyamide) is used for adsorption, and after elution, it is separated from other flavonoids by chromatography or purified by high pressure liquid chromatography (HPLC).

Details:

Kaempferol

Mol Download Chemical properties

CAS:

520-18-3

MF:

C15H10O6

MW:

286.24

EINECS:

208-287-6

MDL No.:

MFCD00016938

Properties

Melting point:

276°C

Boiling point:

348.61°C (rough estimate)

Density 

1.2981 (rough estimate)

refractive index 

1.4413 (estimate)

storage temp. 

2-8°C

solubility 

ethanol: 20 mg/mL

pka

6.34±0.40(Predicted)

form 

powder

Colour Index 

75640

color 

yellow

Merck 

14,5274

BRN 

304401

Stability:

Unstable in Solution

InChIKey

IYRMWMYZSQPJKC-UHFFFAOYSA-N

LogP

2.685 (est)


Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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