Top Quality Natural...

Top Quality Natural Demethyl tetrandrine
Top Quality Natural Demethyl tetrandrine
Top Quality Natural Demethyl tetrandrine
Top Quality Natural Demethyl tetrandrine

Top Quality Natural Demethyl tetrandrine

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 35.0000 -49.0000
  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : T/T,Other

Keywords

Demethyl tetrandrine 33889-68-8 Fangchinoline

Quick Details

  • Appearance:white powder
  • Application:Pharmaceutical;Food Preservative;Cosmetics;Food
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:5000|Kilogram|Month
  • Storage:in a cool&dry place
  • Transportation:By air,By Sea

Superiority:

33889-68-8 - Physico-chemical Properties

Molecular Formula C37H40N2O6
Molar Mass 608.72
Density 1.204±0.06 g/cm3(Predicted)
Melting Point 240～242℃
Boling Point 709.7±60.0 °C(Predicted)
Specific Rotation(α) ＋255．1°（），＋275°（C=0．57，）
Flash Point 383°C
Solubility 100 mg/mL in DMSO
Vapor Presure 8.25E-21mmHg at 25°C
Appearance Brown powder
Color White to Orange to Green
pKa 9.38±0.20(Predicted)
Storage Condition 2-8℃
Refractive Index 1.601
MDL MFCD00221726
Physical and Chemical Properties From the tetrandra S. Moore, a plant of the family tetrandra

33889-68-8 - Reference Information

overview [1-3] Fangzonolinine (Fangchinoline), also known as HanFangji and Aquilaria sinensis, is the dry root of Fangji plant FenFangji. It has many biological functions such as anti-inflammatory and analgesic, antioxidant, non-specific blocking of calcium ion channels, inhibiting histamine release, dilating coronary arteries, reducing myocardial oxygen consumption, inhibiting platelet aggregation, lowering blood pressure, lowering blood sugar, etc. In some cells, the anti-tumor effect can be achieved by blocking the cell cycle and inducing autophagy apoptosis. Fanghexonoline can significantly inhibit the proliferation and metastasis of A375 cells, and can be used as a potential chemotherapy drug for the treatment of melanoma.


picture: chinese defense self
pharmacological action [4] Fangzonolin (fangchinoline,FAN) is often used as an analgesic, anti-rheumatic and anti-hypertensive drug in traditional Chinese medicine. In recent years, its anti-cancer effect has attracted people's attention. Literature indicates that it can inhibit tumor cells by inducing apoptosis, blocking cell cycle progression and inhibiting tumor cell invasion. In addition, as one of the main alkaloids contained in the Fangji plant Fangji, Fanghexine has obvious analgesic, antipyretic, anti-inflammatory, diuretic, coronary artery expansion, blood pressure lowering, anti-cancer and other effects. High-dose or long-term use will have certain toxicity to the liver and kidney, of which liver damage is the most serious, and the degree of damage is proportional to the drug dose. In addition, Fanghexanolin may become a potential drug for the treatment of prostate cancer. The expression of its pro-apoptotic protein Bax and activated Caspase-3 protein also increased significantly, while the Bcl-2 of inhibiting apoptosis protein decreased correspondingly.


picture: structure diagram of nongenoline
determination method [5] the determination methods of tetrandolinine (FAN) mainly include high performance liquid chromatography (HPLC)

, thin layer chromatography (TLC) and capillary electrophoresis (CE). recently, chemiluminescence method has also been reported. The method

is based on the oxidation of Fangzonolin base by potassium permanganate under acidic conditions to produce chemiluminescence, and a new method for the determination of Fangzonolin base by potassium permanganate

academic luminescence system has been established. The method is simple, fast and sensitive.

has been successfully used for the determination of Fangzonolin content in Fangji.
References [1] Guo Bingyu, Zhang Yu, Hui Qiang, et al. Fangjianolin Inhibits Proliferation and Metastasis of Melanoma [J]. Practical Drugs and Clinics, 2016, 19(10):1219-1223.
[2] Xu Xueqin, Ou Hailing, Wang Yuanfu, etc. Determination of Fangjianolin in Fangji by Chemiluminescence [J]. Journal of Fuzhou University, 2008(5):763-766.
[3] Guo Bingyu, Zhang Yu, Hui Qiang, etc. Fangjianolin Enhances Apoptosis of Melanoma Cells Induced by Gemcitabine [J]. Journal of Clinical Military Medicine, 2015, 43(10):1026-1030.
[4] Wu Qiuhua, Wang Chun, wang Zhi, et al. Study on the Interaction between Fangjianolin and Bovine Serum Albumin [J]. Spectroscopy and Spectral Analysis, 2007, 27(12):2498-2501.
[5] Huang Jianguo. Study on the Mechanism of Fangjianolin Inhibiting Proliferation of Prostate Cancer PC-3 Cells [D]. Huazhong University of Science and Technology, 2010.
use used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-inflammatory and analgesic effects; antihypertensive effects; anti-tumor effects; anti-platelet aggregation effects.

 

Details:

Demethyl tetrandrine

 

CAS:

33889-68-8

MF:

C37H40N2O6

MW:

608.72

EINECS:

MDL No.:

Properties

Melting point:

212-4°C (dec. ).

Boiling point:

709.7±60.0 °C(Predicted)

Density 

1.204±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)

pka

9.38±0.20(Predicted)

form 

Solid

color 

Off-White to Pale Beige

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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