High quanlity of RAD140 1182367-47-0

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 100.0000 -200.0000

1 Kilogram

FOB Price:USD 100.0000 -200.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T

Keywords

RAD140 1182367-47-0 Lowest price of RAD140 CAS NO.1182367-47-0 RAD140 White solid 99%;Testolone

Quick Details

Appearance:White solid
Application:RAD140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
PackAge:25kg/bag
ProductionCapacity:100000|Metric Ton|Day
Storage:cool and dry place
Transportation:By air or by ship or by express

Superiority:

RAD140 (also known as Testolone) is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase.

It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.
We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.
Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.

RAD140 exhibited anti-tumor activity in patient-derived xenograft (PDX) models of AR/ER+ breast cancer, as single agent and in combination with inhibitors of CDK4/6 or mTOR
RAD140 inhibited ER signaling and ESR1 mRNA level in the HBCx-22 PDX model.

Details:

Product Information

CAS:	1182367-47-0
MF:	C20H16ClN5O2
MW:	393.83
EINECS:	1592732-453-0

Melting point	179-183oC
Boiling point	687.7±65.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	13.76±0.20(Predicted)
form	Solid
color	White