CasNo.881851-50-9,Larazotide,(881851-50-9) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: 98%
Payment Terms : T/T

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Larazotide 881851-50-9 98%

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ProductionCapacity:1000|Metric Ton|Day
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Superiority:

生物活性Larazotideacetate是一种合成肽，是一种紧密连接(junction)的调节剂。靶点Paracellularpermeability体外研究Larazotideacetateinhibitstheredistributionandrearrangementofzonulaoccludens-1(ZO-1)andactincausedbyAT-1002andgliadinfragmentsinCaco-2andIEC6cells.LarazotideacetateinhibitstheAT-1002-inducedTEERreductionandTJopeninginCaco-2cells.Larazotideacetateinhibitsthetranslocationofagliadin13-merpeptidChemicalbooke,whichhasbeenimplicatedinceliacdisease,acrossCaco-2cellmonolayers.Further,apicallyappliedLarazotideacetateinhibitstheincreaseinTJpermeabilityelicitedbybasolaterallyappliedcytokines.体内研究Whentestedinvivoingliadin-sensitizedHLA-HCD4/DQ8doubletransgenicmice,larazotideacetateinhibitsgliadin-inducedmacrophageaccumulationintheintestineandpreservednormaltightjunctionstructure.

Details:

Larazotide

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH;Larazotideacetate;LARAZOTIDEACETATE(>90%);inhibiChemicalbookt,Larazotideacetate,Larazotide,Inhibitor,GapJunctionProtein

881851-50-9

C34H59N9O12

785.88536

生物活性Larazotideacetate是一种合成肽，是一种紧密连接(junction)的调节剂。靶点Paracellularpermeability体外研究Larazotideacetateinhibitstheredistributionandrearrangementofzonulaoccludens-1(ZO-1)andactincausedbyAT-1002andgliadinfragmentsinCaco-2andIEC6cells.LarazotideacetateinhibitstheAT-1002-inducedTEERreductionandTJopeninginCaco-2cells.Larazotideacetateinhibitsthetranslocationofagliadin13-merpeptidChemicalbooke,whichhasbeenimplicatedinceliacdisease,acrossCaco-2cellmonolayers.Further,apicallyappliedLarazotideacetateinhibitstheincreaseinTJpermeabilityelicitedbybasolaterallyappliedcytokines.体内研究Whentestedinvivoingliadin-sensitizedHLA-HCD4/DQ8doubletransgenicmice,larazotideacetateinhibitsgliadin-inducedmacrophageaccumulationintheintestineandpreservednormaltightjunctionstructure.