CasNo.76932-56-4,Nafarelin,(76932-56-4) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: 98%
Payment Terms : T/T

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Nafarelin 76932-56-4 98%

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ProductionCapacity:1000|Metric Ton|Day
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Transportation:by Sea，Air and Courier

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Uses Narfarrelin is used for the treatment of endometriosis, inflammation and cysts. Its role is mainly through inhibiting the hypothalamic-pituitary-ovarian axis, resulting in a low estrogen state in the body and causing ectopic endometrium atrophy. In addition, nafarelline can also be used to treat central precocious puberty. Endometriosis is an estrogen-dependent disease in which ovarian hormones are necessary for ectopic endometrial growth. Chemical properties NafarelinMonoacetate: C66883N17O13 C2H4O2. Crystallization, melting point 188 ~ 190℃. ^[α]D25-27.4°(C=0.9, ethylchemicalbook acid). It is an analogue of gonadotropin-releasing hormone (GnRH). Used in the treatment of endometriosis, can eliminate pain, reduce endometrial damage. Production method N-acetyl-2-cyanoglycine ethyl ester is reacted with 2-bromomethylnaphthalene in ethanol and then acid hydrolyzed to obtain compound (I). (Ⅰ) is first acetylated and then ester with methanol to produce compound (Ⅱ). (Ⅱ) The D-configuration (Ⅲ) was obtained by separation, and then the compound (Ⅳ) was obtained by hydrolysis with 6mol/L hydrochloric acid. (Ⅳ) was converted into N-tert-butoxycarbonyl derivative (V), which was synthesized by solid phase method on diphenylmethylamine resin.

Details:

Uses Narfarrelin is used for the treatment of endometriosis, inflammation and cysts. Its role is mainly through inhibiting the hypothalamic-pituitary-ovarian axis, resulting in a low estrogen state in the body and causing ectopic endometrium atrophy. In addition, nafarelline can also be used to treat central precocious puberty. Endometriosis is an estrogen-dependent disease in which ovarian hormones are necessary for ectopic endometrial growth. Chemical properties NafarelinMonoacetate: C66883N17O13 C2H4O2. Crystallization, melting point 188 ~ 190℃. ^[α]D25-27.4°(C=0.9, ethylchemicalbook acid). It is an analogue of gonadotropin-releasing hormone (GnRH). Used in the treatment of endometriosis, can eliminate pain, reduce endometrial damage. Production method N-acetyl-2-cyanoglycine ethyl ester is reacted with 2-bromomethylnaphthalene in ethanol and then acid hydrolyzed to obtain compound (I). (Ⅰ) is first acetylated and then ester with methanol to produce compound (Ⅱ). (Ⅱ) The D-configuration (Ⅲ) was obtained by separation, and then the compound (Ⅳ) was obtained by hydrolysis with 6mol/L hydrochloric acid. (Ⅳ) was converted into N-tert-butoxycarbonyl derivative (V), which was synthesized by solid phase method on diphenylmethylamine resin.