CasNo.1392278-76-0,iRGD,(1392278-76-0) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: 98%
Payment Terms : T/T

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iRGD 1392278-76-0 98%

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PackAge:According to your needs
ProductionCapacity:1000|Metric Ton|Day
Storage:storage temp
Transportation:by Sea，Air and Courier

Superiority:

iRGDpeptide-mediatedtumorpenetrationoccursinthreesteps:bindingtoαv-integrinsontumorvasculatureortumorcells,exposurebyproteolysisofaC-terminalmotifthatbindstoneuropilin-1(NRP-1)andcellinternalization.iRGDpeptideinsertedintheICOVIR15KfiberCterminusenhancesbindingandinternalizationonlyinMCF7cells,whichexpressNRP-1andintegrins.iRGDinsertiondoesnotimpairvirusinfectionandreplication.iRGDpeptidealonehasnoobviouseffeChemicalbookctongastriccancercells,andwhencombinedwith5-FU,iRGDpeptide(0.3μmol/mL)enhancesthechemotherapyefficacyof5-FUongastriccancercellsthroughNRP1.体内研究iRGDinsertedintheoncolyticadenovirusICOVIR15K(ICOVIR15K-iRGD)enhancesearlyadenovirusdisseminationthroughthetumormassandelevatestheantitumoreffectinmice.iRGD(4mmol/kg,i.v.)incombinationwith5-FUsignificantlysuppressesthetumorgrowthinnudemicebearinghumangastriccancercells.

Details:

iRGDpeptide-mediatedtumorpenetrationoccursinthreesteps:bindingtoαv-integrinsontumorvasculatureortumorcells,exposurebyproteolysisofaC-terminalmotifthatbindstoneuropilin-1(NRP-1)andcellinternalization.iRGDpeptideinsertedintheICOVIR15KfiberCterminusenhancesbindingandinternalizationonlyinMCF7cells,whichexpressNRP-1andintegrins.iRGDinsertiondoesnotimpairvirusinfectionandreplication.iRGDpeptidealonehasnoobviouseffeChemicalbookctongastriccancercells,andwhencombinedwith5-FU,iRGDpeptide(0.3μmol/mL)enhancesthechemotherapyefficacyof5-FUongastriccancercellsthroughNRP1.体内研究iRGDinsertedintheoncolyticadenovirusICOVIR15K(ICOVIR15K-iRGD)enhancesearlyadenovirusdisseminationthroughthetumormassandelevatestheantitumoreffectinmice.iRGD(4mmol/kg,i.v.)incombinationwith5-FUsignificantlysuppressesthetumorgrowthinnudemicebearinghumangastriccancercells.