Argipressin 113-79-1 98
Argipressine Basic information
Product Name: Argipressine
Synonyms: [ARG8]-VASOPRESSIN (HUMAN, BOVINE, OVINE, RAT, MOUSE);[ARG8]-VASOPRESSIN;[ARG8]-VASOPRESSIN (AVP);ANTIDIURETIC HORMONE;AVP;BETA-HYPOPHAMINE;β-Hypophamine;(ARG8)-VASOPRESSIN GRADE VI SOLUTION*APP ROX. 100 I.
CAS: 113-79-1
MF: C46H65N15O12S2
MW: 1084.24
EINECS: 204-035-4
Product Categories: Amino Acid Derivatives;Vasopressin and Oxytocin receptor;Peptide Receptors;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Peptide;113-79-1
Mol File: 113-79-1.mol
Argipressine Chemical Properties
density 1.59±0.1 g/cm3(Predicted)
Fp 113℃
storage temp. 2-8°C
pka 9.90±0.15(Predicted)
PH ~3.5
Water Solubility Water : ≥ 360 mg/mL (332.03 mM)
Sequence H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2,(Disulfide bond)
InChIKey KBZOIRJILGZLEJ-KIIOGHSHNA-N
Safety Information
Hazard Codes Xn
Risk Statements 20
Safety Statements 36
WGK Germany 3
HS Code 2937190000
Toxicity TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000
MSDS Information
Provider Language
SigmaAldrich English
Argipressine Usage And Synthesis
Uses Hormone (antidiuretic).
Uses [Arg8]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.
Definition ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
Indications ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V2 that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V2 receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V3 (or V1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.
Brand name Pitressin (Parke-Davis).
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