CasNo.720720-96-7,factory supply Edoxaban N-1 720720-96-7,(720720-96-7) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.9% by HPLC
Payment Terms : L/C,T/T,Other

Keywords

Rivaroxaban edoxaban 720720-96-7

Quick Details

Appearance:White crystallization
Application:treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Edoxaban .Our mfr is Chinese GMP certified for this item with DMF/CEP document.

Product Name:	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
Synonyms:	4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;EthanediaMide iMpurity B HCL;5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;Thiazolo[5,4-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-5-Methyl-, hydrochloride (1:1);5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(for Edoxaban);4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridin;4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid HCl
CAS:	720720-96-7
MF:	C8H11ClN2O2S
MW:	234.7
EINECS:	858-363-3
Product Categories:
Mol File:	720720-96-7.mol

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Chemical Properties

Melting point	199.0 to 203.0 °C
Boiling point	175℃[at 101 325 Pa]
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly)
form	Solid
color	Pale Beige to Light Brown
Stability:	Hygroscopic

Details:

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Usage And Synthesis

Uses

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).

Preparation

2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.61 mg), ethanol (5 mL), and 4N aqueous lithium hydroxide (1.34 mL) were mixed at room temperature, and the resultant mixture was stirred at 50 °C for 7 hours. Until the reaction mixture was cooled with ice-water, 1N HCl in ethanol (7.5 mL) was added to the mixture. It was stirred for 1.5 hours. The precipitated crystals were collected by filtration, and were washed with ethanol (2 mL). The wet crystal was dried at room temperature under reduced pressure to obtain 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride.