CasNo.545445-44-1,factory supply Apixaban N-2 545445-44-1,(545445-44-1) Suppliers

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Purity: 99.9% by HPLC
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Keywords

edoxaban Apixaban 545445-44-1

Quick Details

Appearance:White crystallization
Application:treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Apixaban .Our mfr is Chinese GMP certified for this item with DMF/CEP document.

Product Name:	3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms:	5-morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-2,3-dihydropyridin-6-one;3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one;3-Morpholino-1-(4-(2-oxopiperidin-1-yl);HSK00001094;Apixaban Impurity H;Apixaban Intermediates;Apixaban Impurity P;3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one
CAS:	545445-44-1
MF:	C20H25N3O3
MW:	355.43
EINECS:	1308068-626-2
Product Categories:
Mol File:	545445-44-1.mol

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties

Melting point	>199°C (dec.)
Boiling point	625.0±55.0 °C(Predicted)
density	1.267
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	3.25±0.20(Predicted)
color	Pale Beige

Details:

Uses

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy can be used as an organic synthesis intermediate, mainly used in laboratory research and development and chemical production processes.

Synthesis

2 g compound C (compound Ib) and 50 ml acetonitrile were added into a three-necked flask to obtain a turbid solution. The turbid solution was stirred and cooled to 0 C. in an ice bath. 1.75 g (6 eq) sodium hydroxide was added and stirred in the ice bath for 10 min. Then 1.9 ml of 5-chloro-valeryl chloride (2 eq) (diluted with 2 ml acetonitrile) was dropwise added while controlling the temperature to 0-5 C. After completing the addition, the ice bath was removed and the temperature was naturally raised to 30 C. The reaction was performed for 5 hours. After observing the absence of the starting material and the intermediate state of the reaction, the reaction solution was cooled to 0 C. in an ice bath, and adjusted to a neutral pH with 6 N of hydrochloric acid. The reaction solution was concentrated to dryness, pulpifying for 1 hour after adding 8 ml saturated sodium bicarbonate solution, and filtered to obtain 2.29 g yellow solid. Yield: 87.5%. Purity: 95.3% (HPLC). EI-MS (m/z): 355.2. HNMR (400 MHz, DMSO, ppm) | 7.32 (d, J=8.8 Hz, 2H), 7.26 (d, J=8.8 Hz, 2H), 5.71 (t, J=4.8 Hz, 1H), 3.72-3.69 (m, 2H), 3.65-3.63 (m, 4H), 3.60-3.57 (m, 2H), 2.79-2.77 (m, 4H), 2.44-2.41 (m, 2H), 2.40-2.39 (m, 2H), 1.88-1.82 (m, 4H).