Framycetin sulphate

Details:

Framycetin sulfate is an aminoglycoside antibiotic derived from Streptomyces bacteria, specifically identified as Neomycin B in its sulfate salt form. Here's a structured overview:

Drug Class:

Aminoglycoside antibiotic, closely related to neomycin. It is a component of the neomycin complex, which also includes Neomycin C and Neomycin A.

Mechanism of Action:

Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to misreading of mRNA and cell death. Effective against Gram-negative bacteria (e.g., E. coli, Klebsiella) and some Gram-positive bacteria.

Uses:

Topical applications to treat superficial infections:

Skin infections (e.g., cuts, burns, infected eczema).                                                                                                                                                        Eye infections (conjunctivitis).                                                                                                                                                                                          Ear infections (otitis externa).                                                                                                                                                                                            Often combined with other antibiotics (e.g., gramicidin, dexamethasone) in creams, ointments, or drops (e.g., Soframycin®, Neosporin® variants).

Formulation:

Administered as a sulfate salt to enhance solubility and stability in topical preparations.

Side Effects:

Local reactions: Irritation, redness, itching.

Allergic reactions: Contact dermatitis (rare but possible).

Caution: Prolonged use on broken skin may lead to systemic absorption, risking ototoxicity or nephrotoxicity (though rare with topical use).

Resistance & Precautions:

Not effective against anaerobic bacteria or Pseudomonas aeruginosa.

Resistance can develop with misuse; avoid over-the-counter prolonged use.

Key Note:

Framycetin sulfate is distinct from systemic aminoglycosides (e.g., gentamicin) due to its localized application, minimizing severe side effects. Always used under medical guidance to prevent resistance.