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Azelnidipine Azelnidipine powder Azelnidipine supplier
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Azelnidipine
Product Name: Azelnidipine
CAS: 123524-52-7
MF: C33H34N4O6
MW: 582.65
EINECS: 634-143-0
Melting point: 120-126°C
Boiling point: 709.3±60.0 °C
Density: 1.33±0.1 g/cm3
Storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Appearance: yellow powder
Description:
Azelnidipine, a member of the 1,4-dihydropyridine class of L-type calcium channel blockers with a slow onset profile, was marketed in Japan for the treatment of hypertension. Azelnidipine is synthesized via the condensation of iso-propyl 2-(3- nitrobenzylidene)acetoacetate with (1-diphenylmethylazetidin-3-yl)-3,3-diamino acrylate. The diamino acrylate intermediate is prepared from the cyanoacetic ester by sequential treatment with HCl and ammonia. In receptor binding studies using porcine heart membrane fractions, azelnidipine exhibits an IC50 of 3.1 nM and an apparent Ki of 2.1 nM.
Uses:
Azelnidipine is a dihydropyridine calcium channel blocker with antihypertensice activity. Azelnidipine is used for treating ischemic heart disease and cardiac remodeling after myocardial infarction.
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Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / Sales Manager
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