(2-Chlorophenyl) -2-Nitrocyclohexanone

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T

Keywords

CAS 2079878-75-2 (2-Chlorophenyl) -2-Nitrocyclohexanone 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one

Quick Details

Appearance:white crystal
Application:used as an intermediate in organic synthesis and medical chemistry
PackAge:aluminum foil bag,drum
ProductionCapacity:10000|Kilogram|Month
Storage:Store in cool dry place
Transportation:sea, land and air

Superiority:

Yiwu Demei e-commerce firm is a dynamic and innovative enterprise, specializing in the research, manufacture and distribution of high-quality pharmaceutical ingredients and organic compounds. We are firmly committed to promoting the development of the global pharmaceutical industry and promoting the export of China's pharmaceutical products to the world. Our extensive product portfolio has been recognized in key markets. Adhering to the principle of honesty and transparency, we give priority to establishing a trustworthy relationship with customers to ensure the success and long-term cooperative partnership between the two sides.The company is located in Shijiazhuang, Hebei Province, the hub of Beijing-Tianjin-Hebei, and has more than ten years of industry experience. The affiliated factory covers an area of 7000 square meters. In addition, it also has its own excellent talent pool. Our high-tech R&D team has more than 200 R&D personnel in the workshop. In recent years, our products have been exported to Britain,Germany, Australia, the Netherlands, Poland, Russia, Kazakhstan, the Philippines, Malaysia, Singapore and many other regions. We do business with customers on the principle of honesty and trustworthiness. We are committed to satisfying our customers and gaining the greatest recognition from them within the scope permitted by law. We pay attention to every detail and strive to provide customers with the best services in procurement, research and development, quality control and safe transportation, so as to establish long-term cooperative relations with customers.

FAQ
1.What is your minimum order quantity?
Different products have different minimum order quantities.Usually at least one kilogram.For a few ultra-high value products,the minimum order quantity is 1g.
2.What are your payment methods?
Our payment methods include ,Money Gram,Alibaba,Alipay and T/T.
3.How long is your shipping time?
Normally it is shipped the same day or the next day.Due to different countries,the shipping time is also different.Usually ranging from seven to fifteen days.Please consult customer service for details.
4.How can I get the samples?
For some products,we can provide you with free off the shelf samples.You just need to pay for delivery.

5.What services do you provide?
Since the products are mass- produced,customized products,customized purity,and customized packaging are not supported.

Details:

Common Name	2-(2-Chlorophenyl)-2-nitrocyclohexanone
CAS Number	2079878-75-2
Molecular Weight	253.68
Molecular Formula	C12H12ClNO3
EINECS	205-516-1
Density	1.33±0.1 g/cm3(Predicted)
Boiling Point	412.5±45.0 °C(Predicted)
Appearance	white crystal
Storage condition	Store in cool dry place

2-(2- chlorophenyl) -2- nitrocyclohexanone is often used as an intermediate in organic synthesis and pharmaceutical chemistry, mainly used in laboratory research and development process and pharmaceutical chemical production process, and mostly used in drug molecular structure modification and production. For example, the substance can be used for the synthesis of drug molecule norketamine, which is an intravenous general anesthetic with analgesic effect. It can selectively inhibit the medial thalamic nucleus, block the ascending conduction of spinal reticular structure bundle and excite the limbic system. In addition, it also has a certain affinity for opioid receptors in the central nervous system.

2-(2- chlorophenyl) -2- nitrocyclohexanone, with the English name of 2-(2-chlorophenyl)-2-nitrocyclohexanone, is a cyclohexanone derivative, which is often used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used for the synthesis of pharmaceutical molecules and bioactive molecules, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes. For example, 2-(2- chlorophenyl) -2- nitrocyclohexanone is the key synthetic intermediate of drug molecule norketamine.

Constitutive property
2-(2- chlorophenyl) -2- nitrocyclohexanone contains a nitro group and a highly functionalized cyclohexanone unit in its structure. It has two reaction centers, nitro group and carbonyl group, and can carry out various chemical reactions, such as addition reaction, reduction reaction and substitution reaction, showing high chemical reaction activity. 2-(2- chlorophenyl) -2- nitrocyclohexanone is relatively stable at room temperature, but it is easy to decompose at high temperature, strong acid, strong alkali and other conditions to generate toxic gas.

Production method
In argon atmosphere, the activated zinc powder (6 equivalents) was slowly added to the solution of 2-(2- chlorophenyl) -2- nitrocyclohexanone (50.7 mg) in acetic acid (2.0 ml) with stirring. The reaction mixture 12 obtained by stirring at room temperature is small. Aft that reaction, the reaction mixture is directly filtered to remove insoluble solid in the reaction solution. The filtrate was then concentrated under reduced pressure, and the resulting residue was diluted with dichloromethane. The residue was washed with saturated sodium bicarbonate (5.0mL) and the aqueous phase was extracted with dichloromethane (3×10 mL). Then the combined organic layers were dried on anhydrous Na2SO4. The organic layer was filtered to remove the desiccant and concentrated under vacuum to remove the solvent. The obtained residue was separated and purified by silica gel chromatography (petroleum ether/ethyl acetate, 1:1) to obtain the target product molecule.

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