(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile

Details:

Purpose:

GS-441524 is a small molecule, riboside triphosphate competitive inhibitor, that has demonstrated strong antiviral activity against many RNA viruses. It can inhibit the replication of several different types of RNA viruses, such as zoonotic Severe Acute Respiratory syndrome (SARS) coronavirus, Middle East Respiratory syndrome virus, Ebola virus, Lassa fever virus, Junin virus, and respiratory syncytial virus, while having low cytotoxicity in a wide range of cell lines.

Mechanism of action:
GS-441524 is phosphorylated intracellular to nucleoside monophosphate (NMP) by cellular kinase and then converted to an active triphosphate metabolite (NTP structural analogue). In viral RNA synthesis, active NTP structural analogs act as competitors of natural nucleosides triphosphate (ATP, TTP, CTP, GTP) to participate in RNA transcription. When GS-441524 molecule is inserted into the transcription product, transcription will be prematurely terminated, thus inhibiting the viral RNA transcription process.
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Company Introduction

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

Our advantages

1) Timely communication, reply within 12 hours.You can leave any messages on our whats app or send email to us.

2)Selecting raw materials strictly,our products are the highest purity.

3)Reasonable and competitive price.

4) Free sample for your evaluation.Customers only need to undertake the shipping fee for delivery the samples to your destionation.

5)OEM/ODM Available.Trial order is available for testing after samples.

6) Packaging can be customized according to each buyers' special request.

We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.

We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.

After Sales Service

1) Best quality in your requirement

2)Competitive price in china market

3)Mature technical support

4)Professional logistic support

5 )Full experience of large numberscontainers loading in chinese sea port

6 )Fast shipment by reputed shipping line

7) Packing with pallet as buyer's special request

8) Best service after shipment.

9) Cargoes together with container after-sales service available

10) Full experience in export

11)Raw materials from chinese origin

FAQ

1.What is the way you ship

Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc

Our way of shipping the products is universal and secure.

The company name and other contents related to pharmacy are not written on the package slips.

The way of packing is regularly changed for a secure delivery.

The packages are small in order to avoid unwelcomed questions . If the order is big, then it will be divided into two or more packages

2.Can the packages be trackable

YES, we provide tracking number and you can track on internet.

3.Where do you ship to

Worldwide.

4.Do you offer domestic shipping/remail shipping

Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.

5.Do you ensure your packing, what about customs, what happens if the package is retained

We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.

6.Which payment options are available

Bitcoin,,Bank wire,MoneyGram

 

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