Rimantadine

The IUPAC name of Tricyclo[3.3.1.1^3,7]decane-1-methanamine,α-methyl- is 1-(1-adamantyl)ethanamine. With the CAS registry number 13392-28-4, it is also named as Rimantadine. The product's categories are Adamantane Derivatives; API's. In addition, its molecular formula is C₁₂H₂₁N and molecular weight is 179.30.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.10; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): 0.08; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.11; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.545; (14)Molar Refractivity: 54.89 cm³; (15)Molar Volume: 173.4 cm³; (16)Polarizability: 21.76×10^-24cm³; (17)Surface Tension: 41.3 dyne/cm; (18)Density: 1.033 g/cm³; (19)Flash Point: 99.3 °C; (20)Enthalpy of Vaporization: 48.5 kJ/mol; (21)Boiling Point: 247.8 °C at 760 mmHg; (22)Vapour Pressure: 0.0251 mmHg at 25 °C.

Preparation of Tricyclo[3.3.1.1^3,7]decane-1-methanamine,α-methyl-: this chemical can be prepared by 1-Adamantan-1-yl-ethanone.



This reaction needs HCOONH₄ and Formic acid by heating for 10 hours. The yield is 85 %.

Uses of Tricyclo[3.3.1.1^3,7]decane-1-methanamine,α-methyl-: this chemical is believed to inhibit influenza's viral replication, possibly by preventing the uncoating of the virus's protective shells, which are the envelope and capsid. Besides, it possesses some NMDA antagonistic properties and is used as an antiparkinsonic drug. Moreover, it can react with Formaldehyde to get (+-)-([1]Adamantyl-ethyl)-dimethyl-amin.



This reaction needs HCOOH and H₂O at temperature of 80 °C for 21 hours. The yield is 94 %.

People can use the following data to convert to the molecule structure.
(1)SMILES: NC(C)C13CC2CC(CC(C1)C2)C3
(2)InChI: InChI=1/C12H21N/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12/h8-11H,2-7,13H2,1H3
(3)InChIKey: UBCHPRBFMUDMNC-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C12H21N/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12/h8-11H,2-7,13H2,1H3
(5)Std. InChIKey: UBCHPRBFMUDMNC-UHFFFAOYSA-N