PHOSPHORIC ACI DI-T...

PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER

PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99.9% by HPLC
  • Payment Terms : L/C,T/T,Other

Keywords

phosphoric acid di-t-butyl ester chloromethyl ester di-tert-butyl chloromethyl phosphonate 229625-50-7

Quick Details

  • Appearance:White crystallization
  • Application:can be used primarily to treat ascites in patients with liver disease,low-renin hypertension,hypokalemia,and Connsyndrome.
  • PackAge:25kg/drum
  • ProductionCapacity:10|Metric Ton|Day
  • Storage:in room temperature
  • Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Fosnetupitant .Our mfr is Chinese GMP certified for this item with DMF document.

 

Product Name: Di-tert-butyl Chloromethyl Phosphate
Synonyms: Di-tert-butyl Chloromethyl Phosphate;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER;Phosphoric acid, chloroMethyl bis(1,1-diMethylethyl) ester;Phosphoric acid di-tert-butyl chloromethyl ester;Chloromethyl di-tert-butyl phosphate;Phosphoric acid ditert-butyl ester chloromethyl ester;Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate);Fostemsavir-SM
CAS: 229625-50-7
MF: C9H20ClO4P
MW: 258.68
EINECS:  
Product Categories: intermediates;SiChem
Mol File: 229625-50-7.mol
Di-tert-butyl Chloromethyl Phosphate Structure
 

Details:

Description Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].
Uses Used as an intermediate for laboratory research.
Synthesis Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs,  is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .
References [1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.
 
Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials
Raw materials Methanaminium, N,N,N-trimethyl-, bis(1,1-dimethylethyl) phosphate (1:1)-->Chloromethyl chlorosulfate-->DI-T-BUTYL PHOSPHORIC ACID-->DI-TERT-BUTYLPHOSPHATE, TETRABUTYLAMMONIUM SALT-->Chloromethanesulfonyl chloride-->DI-TERT-BUTYL PHOSPHITE-->Potassium di-tert-butyl phosphate-->Dibenzyl phosphate

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