3-PYRIDINAMINE, N-M...

3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99.9% by HPLC
  • Payment Terms : L/C,T/T,Other

Keywords

290297-25-5 N-Methyl-4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinamine Netupitant N-1

Quick Details

  • Appearance:White crystallization
  • Application:treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
  • PackAge:25kg/drum
  • ProductionCapacity:10|Metric Ton|Day
  • Storage:
  • Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Netupitant .Our mfr is Chinese GMP certified for this item with DMF/CEP document.

Product Name: 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
Synonyms: 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-;Netupitant N-1;N-Methyl-4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinamine;N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine;methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine;N-Methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)-3-aminopyridine;Netupitant ITS-3;N-Methyl-4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinamine Oxalic acid
CAS: 290297-25-5
MF: C18H24N4
MW: 296.41
EINECS: 1592732-453-0
Product Categories:  
Mol File: 290297-25-5.mol
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Structure
 
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Chemical Properties
Boiling point  478.2±45.0 °C(Predicted)
density  1?+-.0.06 g/cm3(Predicted)
pka 9.73±0.38(Predicted)

Details:

3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Usage And Synthesis
Uses N-Methyl-4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinamine is used as a reactant in the synthesis of NK1 receptor antagonists via 1,4-Grignard addition/oxidation sequence to 6-chloronicotinic acid and derivatives.
 
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Preparation Products And Raw materials
Raw materials 3-PYRIDINECARBOXAMIDE, N-(1,1-DIMETHYLETHYL)-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)--->6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine-->6-CHLORO-4-O-TOLYL-NICOTINAMIDE-->N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide-->6-CHLORO-4-O-TOLYL-NICOTINIC ACID-->N-(6-(4-Methylpiperazin-1-yl)pyridin-3-yl)pivalaMide-->N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide-->2-(4-Methylpiperazin-1-yl)-5-nitropyridine-->O-TOLYLMAGNESIUM CHLORIDE-->Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate-->3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)--->2-Chloro-5-nitropyridine-->1-Methylpiperazine-->6-Chloronicotinic acid

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