Stereoisomer of 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34, 34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3- methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14, 20, 26-hexamethyl-23,27-ep RAP 53123-88-9
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Product Name: | Rapamycin |
Synonyms: | AY 22989;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;NSC-226080;RAPA;RAPAMUNE;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM |
CAS: | 53123-88-9 |
MF: | C51H79NO13 |
MW: | 914.17 |
EINECS: | 610-965-5 |
Product Categories: | VIVACTIL;antibiotic;Chiral Reagents;Heterocycles;Inhibitor;11;Immunosuppressant;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Signalling;API;Active Pharmaceutical Ingredients;53123-88-9 |
Mol File: | 53123-88-9.mol |
Rapamycin Chemical Properties |
Melting point | 183-185°C |
Boiling point | 799.83°C (rough estimate) |
alpha | D25 -58.2° (methanol) |
density | 1.0352 (rough estimate) |
vapor pressure | 0.56 hPa ( 20 °C) |
refractive index | 1.5280 (estimate) |
Fp | 87 °C |
storage temp. | -20°C |
solubility | ethanol: soluble2MM |
form | solution |
pka | 10.40±0.70(Predicted) |
color | colorless to yellow |
Water Solubility | Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water. |
Sensitive | Moisture Sensitive/Light Sensitive/Hygroscopic |
Merck | 14,8114 |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 53123-88-9(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xi,Xn,F |
Risk Statements | 36/38-36-20/21/22-11 |
Safety Statements | 22-24/25-37/39-26-36/37-16 |
RIDADR | UN 1648 3 / PGII |
WGK Germany | 2 |
RTECS | VE6250000 |
Autoignition Temperature | 301 °C |
HS Code | 29349990 |
Hazardous Substances Data | 53123-88-9(Hazardous Substances Data) |
Toxicity | LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina) |
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