BAF-312(SiponiMod) SiponiMod 3-Azetidinecarboxylic acid
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Product Name: BAF-312(SiponiMod)
CAS: 1230487-00-9
MF: C29H35F3N2O3
MW: 516.59
Melting point 154 - 157°C
Boiling point 602.0±65.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 2.69±0.20(Predicted)
form Solid
color White to Off-White
Description S1p signaling is important for immune, cardiovascular, and CNS function.Like its FDA approved predecessor fingolimod, siponimod is an oral S1p signaling modulator.While fin- golimod binds four out of five known S1p receptors, siponimod is selective for receptor sub- types 1 and 5. This selectivity may allow for an improved adverse event profile.
Uses Siponimod is a functional sphingosine -1 phosphate (SIP) antagonist used in the treatment of multiple sclerosis and other central nervous system-related diseases in human subjects. .
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