CasNo.1335210-35-9,(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide,(1335210-35-9) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.9% by HPLC
Payment Terms : L/C,T/T,Other

Keywords

(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide Dolutegravir 1335210-35-9

Quick Details

Appearance:White crystallization
Application:treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Dolutegravir .Our mfr is Chinese GMP certified for this item with DMF document.

Product Name:	O-Methyl Dolutegravir
CAS:	1335210-35-9
MF:	C21H21F2N3O5
MW:	433.41
EINECS:
Product Categories:	CMLLYL
Mol File:	1335210-35-9.mol

O-Methyl Dolutegravir Chemical Properties

Boiling point	684.3±55.0 °C(Predicted)
density	1.45±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	10.70±0.40(Predicted)

Safety Information

HS Code

38220090

Details:

Description	Dolutegravir intermediate is a new synthetic intermediate of Dolutegravir. Dolutegravir is an integrase inhibitor used to treat human immunodeficiency virus (HIV)-1 infection.
Uses	(4R,12AS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide is an intermediate in the preparation of dolutegravir, an integrase inhibitor for HIV-1 infection therapy.
Synthesis	(3S,11aR)-3-methyl-6-(methyloxy)-5,7-dioxo-2,3,5,7,11,11a- hexahydro[1,3]oxazolo [3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid (100 gm) and carbonyl dimidazole (78.89 gm) was suspended in acetonitrile (1000 mL). The mixture was heated to 75°C and stirred for 1 hour. The resulting solution was cooled to a temperature of 20°C and treated with 2,4- difluorobenzyl amine solution (55.2 gm was dissolved in 200 mL of acetonitrile). The reaction mixture was maintained for 2 hours, concentrated, and the compound was extracted with ethyl acetate (1000 mL). Isopropyl alcohol (500 mL) was added at 40°C, stirred the reaction mass for 30 minutes at a temperature of 50°C, and cooled the reaction mass to 25°C. The reaction mixture was maintained for 8 hours at the same temperature. The product O-Methyl Dolutegravir was collected by filtration and dried under vacuum (85 gm).

O-Methyl Dolutegravir Preparation Products And Raw materials

Raw materials	(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid-->2,4-Difluorobenzylamine
Preparation Products	Dolutegravir sodium