CasNo.203849-91-6,MonoMethyl Dolastatin 10,(203849-91-6) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 99%
Payment Terms : T/T

Keywords

DeMethyldolastatin 10 MMAD MonoMethyl Dolastatin 10

Quick Details

Appearance: Powder
Application: MMAD is a tubulin inhibitor and used to produce site-specific antibody drug conjugates.
PackAge:according to the customer
ProductionCapacity:100|Metric Ton|
Storage: Sealed in dry,Store in freezer, under -20°C
Transportation:by air sea and courier

Superiority:

mmad is a highly potent inhibitor of tubulin [1].mmad is one of the auristatins, which are used as the drugs of antibody drug conjugates (adcs). in adcs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of mabs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. as a payload of adcs, mmad is used to target the tubulin of the tumor cells. it can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1].additionally, mmad is reported to be used in the production of site-specific antibody drug conjugates (ndcs). in the ndcs, mmad is combined with anti-5t4 antibody or anti-her2 antibody. it is shown that the ndcs demonstrate better efficacy and pharmacokinetics

Details:

mmad is a highly potent inhibitor of tubulin [1].mmad is one of the auristatins, which are used as the drugs of antibody drug conjugates (adcs). in adcs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of mabs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. as a payload of adcs, mmad is used to target the tubulin of the tumor cells. it can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1].additionally, mmad is reported to be used in the production of site-specific antibody drug conjugates (ndcs). in the ndcs, mmad is combined with anti-5t4 antibody or anti-her2 antibody. it is shown that the ndcs demonstrate better efficacy and pharmacokinetics

puja sapra, andrea t hooper, christopher j, o’donnell & hans-peter gerber. investigational antibody drug conjugates for solid tumors. expert opin. investig. drugs.