Propargyl-PEG6-acid

Details:

Propargyl-PEG6-acid Chemical Properties
Boiling point     462.8±45.0 °C(Predicted)
density     1.126±0.06 g/cm3(Predicted)
refractive index     n/D 1.469
storage temp.     -20°C
solubility     Soluble in Water
form     liquid
pka    4.28±0.10(Predicted)
color     Colorless to light yellow

Propargyl-PEG6-acid Usage And Synthesis
Description    Propargyl-PEG6-acid comprises propargyl and carboxylic acid functional groups. The acid group reacts with primary amines in the presence of activators (e.g. EDC, or HATU).The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The molecule has good solubility in aqueous environment.
Uses    This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.