Indacaterol maleate 753498-25-8 ndacaterol Maleate
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Product Name: Indacaterol Maleate
CAS: 753498-25-8
MF: C28H32N2O7
MW: 508.57
EINECS: 691-329-4
Melting point 195-197°C (dec.)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Pale Beige
Chemical Properties White Solid
Uses A long-acting β2 adrenoreceptor agonist and bronchodilator, for the treatment of asthma and chronic obstructive pulmonary disease.
Mechanism of action Indacaterol works by stimulating adrenergic beta-2 receptors in the smooth muscle of the airways. This causes relaxation of the muscle, thereby increasing the diameter of the airways, which become constricted in asthma and COPD. It is also long acting due to its high affinity to the lipid raft domains in the airway membrane so it slowly dissociates from the receptors. Indacaterol also has a high intrinsic efficacy so it is also very rapid acting - onset of action occurs within 5 minutes.
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