L-Glutamicacid

L-Glutamicacid
L-Glutamicacid
L-Glutamicacid

L-Glutamicacid

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  • Purity: HPLC≥98%

Keywords

56-86-0 L-Glutamicacid High quality

Quick Details

  • Appearance:detailed see specifications
  • Application:analysis,activity test,Botanical Refer...
  • PackAge:According to the clients requirement.
  • ProductionCapacity:||
  • Storage:Store at 2~8°C
  • Transportation:by air or by ocean shipping

Superiority:

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library


1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details:

Chemical Properties of L-Glutamic acid

Cas No. 56-86-0    
PubChem ID 33032 Appearance White powder
Formula C5H9NO4 M.Wt 147.1
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble to 100 mM in 1eq. NaOH
Chemical Name (2S)-2-aminopentanedioic acid
SMILES C(CC(=O)O)C(C(=O)O)N
Standard InChIKey WHUUTDBJXJRKMK-VKHMYHEASA-N
Standard InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of L-Glutamic acid

The Semen Trigone

Biological Activity of L-Glutamic acid

Description L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system. L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands.

Protocol of L-Glutamic acid

Structure Identification

Nature, 1974 , 248 (5451) :804-5.

Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid[Reference: WebLink]

L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system1.
METHODS AND RESULTS:
The L-Glutamic acid molecule is relatively flexible, and in an attempt to gain some insight into its possible shape(s) during activation of receptors associated with excitation of central neurones, a study was made of four conformationally restricted analogues: (±)-cis-1-aminocyclohexane-1,3-dicarboxylic acid (‘cyclo-glutamic’ acid), ibotenic acid, kainic acid and its dihydro derivative.

Bioconjug. Chem., 1999 , 10 (1) :137-40.

L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands.[Reference: WebLink]


METHODS AND RESULTS:
Bisalkylation of suitably protected L-Glutamic acid and L-lysine derivatives with tert-butyl N-(2-bromoethyl)iminodiacetate 2, followed by deprotection of the omega functional group affords N, N-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]-L-Glutamic acid 1-(1, 1-dimethylethyl) ester 4 and N2,N2-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]-L-lysine 1,1-dimethylethyl ester 7. Such compounds feature a carboxylic or an amino group, respectively, which are available for conjugation with a suitable partner via formation of an amide bond. The conjugates, which can be prepared in this way, contain a chelating subunit in which all five acetic residues of DTPA are available for the complexation of metal ions. Direct bisalkylation of glycine with 2 promptly gives N, N-bis[2-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]ethyl]glycine 11.
CONCLUSIONS:
The latter allows to achieve conjugates in which the central acetic group of DTPA is selectively converted into an acetamide.

Preparing Stock Solutions of L-Glutamic acid

  1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.7981 mL 33.9905 mL 67.981 mL 135.9619 mL 169.9524 mL
5 mM 1.3596 mL 6.7981 mL 13.5962 mL 27.1924 mL 33.9905 mL
10 mM 0.6798 mL 3.399 mL 6.7981 mL 13.5962 mL 16.9952 mL
50 mM 0.136 mL 0.6798 mL 1.3596 mL 2.7192 mL 3.399 mL
100 mM 0.068 mL 0.3399 mL 0.6798 mL 1.3596 mL 1.6995 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

 

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