Propylene glycol

Superiority:

Propanediol
1, 2-propanediol
CAS: 57-55-6; 123120-98-9
Chemical formula: C3H8O2

Appearance
Colorless viscous stable water-absorbing liquid, almost tasteless, odorless, flammable, low toxicity. It is miscible with water, ethanol and various organic solvents. Boiling point 187.3℃. Melting point -60 ℃. The relative density is 1.0381. Refractive index 1.4326. Surface tension (20℃)38mNm. Viscosity (20℃) 60.5mPa-s. Specific heat capacity (20℃)2.49kj/(kg. ° C). Heat of vaporization (101.3kPa)7Ukj/kg. Heat of combustion (25℃) 1824.OkJ /mol. Flash point (open cup) 99℃. Spontaneous ignition point 415.5℃. Critical temperature 352℃. Critical pressure 6.lMPa.

Preparation
The direct water hydrolysis of propylene oxide is a pressurized non-catalytic hydrolysis method. It is prepared by direct hydration of propylene oxide and water at 150 N160℃, 0.78 ~ 0.98MPa pressure, and the reaction product is evaporated and rectified to obtain the finished product.
The indirect aqueous process of propylene oxide is prepared by the indirect aqueous synthesis of propylene oxide and water with sulfuric acid as catalyst. The equation is the same as above.
Direct catalytic oxidation of propylene.
Use
It is the raw material of unsaturated polyester resin, epoxy resin, polyurethane resin, and also the raw material of plasticizer, surfactant, emulsifier and demulsifier. In the food industry, it is used as a solvent for flavor, food coloring, tobacco wetting agent, anti-mildew agent and fruit ripening preservative, drug excipient, etc. It can also be used as antifreeze, heat carrier and food machinery lubricant.

Security
Toxicity and irritants are minimal, and no victims have been identified to date. Rats were injected intravenously and intraperitoneally with LD50 7000-8000mg /kg and orally with LD502800mg/kg. However, it has also been reported that when added to food and drink in high doses in one sitting, there is a risk of causing fatal sleepiness and kidney disorders.
Although this product does not spontaneously ignite, it is flammable. Long-term storage does not deteriorate, but the opening absorbs moisture. Storage and transportation containers should be made of galvanized iron drums, aluminum or stainless steel. Storage and transportation in accordance with the general provisions of low toxic chemicals.

    Material Safety Data Sheet

SECTION 1: PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product name: 1,2-Propanediol

Synonyms: 1,2-Dihydroxypropane; Methylethylene glycol; Monopropylene glycol;

Mono propylene glycol;Propane-1,2-diol; alpha-Propyleneglycol;

1,2-Propylene glycol ; Propylene glycol;

CAS No.: 57-55-6

EC No.: 200-338-0

Recommended use of the chemical and restrictions on use

Relevant identified uses: Commercial/industrial use

Uses advised against: No data available.

 

SECTION 2: HAZARDS IDENTIFICATION

GHS classification of the substance/mixture

Hazard classes and Hazard categories:

Hazard Statement code(s)

Not a hazardous substance or mixture

Additional information

None

GHS label elements

The product does not need to be labeled.

Other Hazards:

Not available.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

Ingredients information

Chemical

Name

Synonyms

EC No.

CAS

No.

Classification

according to GHS

Concentration

1,2-Propanediol

1,2-Dihydroxypropane; Methylethylene glycol;

Monopropylene glycol; Propylene glycol;

Mono propylene glycol; Propane-1,2-diol;

alpha-Propyleneglycol; 1,2-Propylene glycol ;

200-338-0 57-55-6

NONE

100%

Additional information

Full text of H-statement(s): see section 16.

The rest unspecified ingredients are impurities, and they are not hazard.

SECTION 4: FIRST AID MEASURES

Description of first aid measures

In case of eye contact:

Consult a physician. Show this safety data sheet to the doctor in attendance.

In case of inhalation:

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact:

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Symptoms and effects, acute and delayed

no data available

 

Immediate medical attention and special treatment

no data available

SECTION 5: FIRE-FIGHTING MEASURES

Extinguishing media

Suitable extinguishing media:

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Unsuitable extinguishing media:

Do not use straight streams of water.

Special hazards arising from the substance or mixture

no data available

Special protective equipment and precautions for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

SECTION 6: ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.

Environmental precautions

Do not let product enter drains.

Methods and material for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

Reference to other sections

See Section 13 for information on disposal.

SECTION 7: HANDLING AND STORAGE

Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.

Conditions for safe storage

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive.

SECTION 8 : EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components with workplace control parameters

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Individual protection measures - personal protective equipment

Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved

under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without

touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after

use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Immersion protection Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 480 min

Material tested: Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Splash protection Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 480 min

Material tested: Dermatril® (KCL 740 / Aldrich Z677272, Size M)

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact

the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an

Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be

construed as offering an approval for any specific use scenario.

Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and

amount of the dangerous substance at the specific workplace.

 

Respiratory: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with

multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering

controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.

Protection: Use respirators and components tested and approved under appropriate government standards such as

NIOSH (US) or CEN (EU).

Environmental exposure controls

Do not let product enter drains.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Molecular formula: C3H8O2

Molecular weight: 76.09

Appearance: Liquid.

Colour: Colourless.

Odour: no data available

pH: no data available

Melting point: Melting point/range: -60 °C - lit.

Boiling point: 187 °C - lit.

Flash point: 103 °c

Vapour pressure: 0,11 hPa at 20 °C

Vapour density: 2,63 - (Air = 1.0)

Density: 1,036 g/mL at 25 °C

Water solubility: no data available

Partition coefficient, n-octanol/water: no data available

Auto-ignition temperature: no data available

Explosive properties: no data available

Decomposition temperature: no data available

Additional information

Not available.

SECTION 10: STABILITY AND REACTIVITY

Reactivity :

no data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

Acid chlorides, Acid anhydrides, Oxidizing agents, Chloroformates, Reducing agents

Hazardous decomposition products

Other decomposition products - no data available

SECTION 11: TOXICOLOGICAL INFORMATION

Information on the likely routes of exposure

Acute toxicity:

LD50 Oral - mouse - 20.000 mg/kg

LC50 Inhalation - rat - 14.000 mg/m3

LD50 Dermal - rabbit – 20.800 mg/kg

LD50 Intravenous - dog - 26.000 mg/kg

LD50 Intraperitoneal - rat - 6.660 mg/kg

LD50 Subcutaneous - rat - 22.500 mg/kg

LD50 Intravenous - rat - 6.423 mg/kg

LD50 Intravenous - mouse - 6.630 mg/kg

LD50 Intravenous - rabbit - 6.500 mg/kg

LD50 Intraperitoneal - mouse - 9.718 mg/kg

Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema. Kidney, Ureter, Bladder:Changes in

both tubules and glomeruli. Blood:Changes in spleen.

LD50 Subcutaneous - mouse - 17.370 mg/kg

Remarks: Behavioral:Change in motor activity (specific assay). Behavioral:Muscle contraction or spasticity. Cyanosis

Skin corrosion/irritation:

Skin - Human

Result: Mild skin irritation - 7 d

Serious eye damage/irritation:

Eyes - rabbit

Result: Mild eye irritation

Respiratory or skin sensitization:

no data available

Additional Information:

RTECS: TY2000000

Gastrointestinal disturbance, Nausea, Headache, Vomiting, Central nervous system depression

Delayed and immediate effects/chronic effects

No information available.

CMR effects (Carcinogenicity, Mutagenicity and Toxicity for Reproduction)

Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified

as probable, possible or confirmed human carcinogen by IARC.

SECTION 12: ECOLOGICAL INFORMATION

Ecotoxicity

Toxicity Effect dose Exposure time Species Method

Fish toxicity: mortality NOEC - Pimephales promelas (fathead minnow) - 52.930 mg/l - 96 h

LC50 - Leuciscus idus (Golden orfe) - 5.300 mg/l - 96 h

LC50: 41 - 47 mL/L, 96h static (Oncorhynchus mykiss)

LC50: = 51400 mg/L, 96h static (Pimephales promelas)

LC50: = 51600 mg/L, 96h static (Oncorhynchus mykiss)

LC50: = 710 mg/L, 96h (Pimephales promelas)

Toxicity to daphnia and other aquatic mortality NOEC - Daphnia - 13.020 mg/l - 48 h

Invertebrates EC50 - Daphnia magna (Water flea) - > 10.000 mg/l - 48 h

Freshwater Algae EC50: = 19000 mg/L, 96h (Pseudokirchneriella subcapitata)

Persistence and degradability

Miscible with water Persistence is unlikely based on information available

Bioaccumulative potential

Does not significantly accumulate in organisms.

Mobility in soil

Will likely be mobile in the environment due to its water solubility. log Pow：-0.9

Other adverse effects

no data available

SECTION 13: DISPOSAL CONSIDERATIONS

Waste treatment methods

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste

generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

Additional information

Dispose of this container to hazardous or special waste collection point.

SECTION 14: TRANSPORT INFORMATION

Land transport (ADR/RID)

UN-No.: Not dangerous goods

Official transport designation: PROPYLENE CARBONATE

Class: Not dangerous goods

Classification code: Not dangerous goods

Packing group: Not dangerous goods

Hazard label: Not dangerous goods

 

Sea transport (IMDG-Code)

Proper Shipping Name: Not dangerous goods

Class: Not dangerous goods

UN-No.: Not dangerous goods

Packing group: Not dangerous goods

EmS No.: Not dangerous goods

Marine pollutant: No

Air transport (ICAO-TI/IATA-DGR)

Proper Shipping Name: Not dangerous goods

Class: Not dangerous goods

UN-No.: Not dangerous goods

Packing group: Not dangerous goods

Additional information

Not available.

SECTION 15: REGULATORY INFORMATION

US federal and state regulations

TSCA: No listed on the Inventory.

Other Regulations

OSHA: No listed on the Inventory.

EINECS: Listed

Directive on industrial emissions

(VOCs, 2010/75/EU) VOC: content 100 %

European union regulations

EINECS: 200-338-0

DSD/DPD:

Not on the Inventory

China regulation

IECSC: Not listed on the IECSC inventory.

HS Code: 2905320000

International regulations

Canada (DSL/NDSL) No listed on the Inventory.

Philippines (PICCS), No listed on the Inventory.

Australia (AICS) No listed on the Inventory.

China (IECSC) No listed on the Inventory.

Other chemical inventories

Japan (ENCS) No listed on the Inventory.

Japan (ISHL) No listed on the Inventory.

Korea(KECL). KE-29267

SECTION 16: OTHER INFORMATION

Revision information

Date of previous revision: Not applicable.

Date of this revision: 11/03/2022

Revision summary: New MSDS

Abbreviations and acronyms

GHS Globally Harmonized System of Classification and Labelling of Chemicals.

CAS: Chemical Abstracts Service (division of the American Chemical Society).

EINECS: European Inventory of Existing Commercial Chemical Substances.

RID: European Rail Transport.

IMDG: International Maritime Code for Dangerous Goods.

IATA: International Air Transport Association.

OSHA: The United States Occupational Safety and Health Administration.

TSCA: Toxic Substances Control Act, The American chemical inventory.

HMIS Hazardous Materials Identification System set by OSHA

DSD/DPD: Dangerous Substance Directive (67/548/EEC)/Dangerous Preparation Directive (1999/45/EC).

IECSC: Inventory of existing chemical substances in China.

HS Code: The Harmonized Commodity Description and Coding System by World Customs Organization.

DSL: Domestic Substances List, The Canadian chemical inventory.

WHMIS Workplace Hazardous Materials Information System on Health Canada's Web site.

AICS: The Australian Inventory of Chemical Substances.

ECL: Existing Chemicals List, the Korean chemical inventory.

MITI: Japanese Existing and New Chemical Substances

Declare to reader

The information in this Material Safety Data Sheet (MSDS) was obtained from sources which we believe are reliable.

However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or

methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For

this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising

out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to

be used only for this product. If the product is used as a component in another product, this MSDS information may not be

applicable.

----------------------------------------------- End of the MSDS-----------------------------------------------

 

 

Items	Standard	Results	Unit of Measure
Content	99.50min	99.90	Weight %
Moisture	0.10max	0.02	Weight %
Relative Density	1.038± 0.001	1.039	20°C (g/cm³)
Color	5 max	4.4	APHA Color
Appearance	Colorless transparent liquid
Conclusion	ELIGIBILITY