CasNo.252917-06-9,CHIR-99021,(252917-06-9) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 0.97
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

CHIR-99021 252917-06-9 0.99

Quick Details

Appearance:white to light brown powder
Application:intermediate
PackAge:drum
ProductionCapacity:1|Kilogram|Month
Storage:-20°C
Transportation:According to your request

Superiority:

Product Name:	CHIR-99021
Synonyms:	6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile;CHIR-99021;CT99021;GSK-3 Inhibitor XVI;3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino];CT99021;CHIR99021;CHIR 99021;CT-99021;CT 99021(CHIR 99021)
CAS:	252917-06-9
MF:	C22H18Cl2N8
MW:	465.34
EINECS:	809-015-4
Product Categories:	Inhibitors;Antineoplastic;Anti-cancer&immunity;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File:	252917-06-9.mol

Uses	Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
Uses	A specific GSK-3 inhibitor of GSK-3β and GSK-3α with IC50s of 5 nM and 10 nM, respectively.
Uses	CHIR99021 has been used: in cocktail with small molecules to convert human lung fibroblast cells into neurons as a culture medium supplement in potassium supplemented simplex optimization medium (KSOM) for the culture of blastocysts for chronic inhibition of GSK-3 to investigate its role in corticogenesis

Details:

HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .
We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products.
We supply Multiple solutions for our customers include offering, research ,Contract Manufacturing Organization(CMO),Contract development and manufacturing organization(CDMO) .
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We are willing to become your trustworthy partner with high-quality products and sincere service!

We can provide customers with small quantities with gram level for laboratories research to tonnage level for industrial production Synthesis capacity from 1 liter to 5000 liter is available.