Nicotinic acid(VB3)

Nicotinic acid(VB3)

Nicotinic acid(VB3)

Min.Order / FOB Price:Get Latest Price

500 Kilogram

Negotiable

  • Min.Order :500 Kilogram
  • Purity: 99%MIN
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Nicocidin Efacin Nicocap

Quick Details

  • Appearance:White to off-white powder
  • Application:Pharmaceutical industry
  • PackAge:25kg/bag
  • ProductionCapacity:10|Metric Ton|Day
  • Storage:Dry cool and clean warehouse
  • Transportation:By sea or air

Superiority:

SAFETY DATA SHEETS

According to the UN GHS revision 10

Version: 1.0

Creation Date: July 15, 2019

Revision Date: July 15, 2019

SECTION 1: Identification

1.1GHS Product identifier

Product name

Nicotinic acid

1.2Other means of identification

Product number

-

Other names

Pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid

1.3Recommended use of the chemical and restrictions on use

Identified uses

Industrial and scientific research use.

Uses advised against

no data available

 

SECTION 2: Hazard identification

2.1Classification of the substance or mixture

Eye irritation, Category 2

2.2GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H319 Causes serious eye irritation

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

Response

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Storage

none

Disposal

none

2.3Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Nicotinic acid Nicotinic acid 59-67-6 200-441-0 100%

SECTION 4: First-aid measures

4.1Description of necessary first-aid measures

If inhaled

Fresh air, rest.

Following skin contact

Rinse skin with plenty of water or shower.

Following eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

Following ingestion

Rinse mouth. Give one or two glasses of water to drink.

4.2Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound include impaired liver function, dryness of the skin, anorexia, nausea, vomiting, diarrhea, activation of peptic ulcers, hepatic disease, hyperuricemia and circulatory collapse (after rapid intravenous injection). It may cause temporary flushing and a feeling of warmth, temporary headache, itching, tingling, skin rash and allergies. It may also cause burning of the skin, face and upper trunk and elevation of serum bilirubin. Other symptoms include mild irritation of upper respiratory tract and gastrointestinal disturbances. It may cause dyspepsia, hyperpigmentation, decrease in excretion of bromosulfophthalein, increase of plasma transaminase activities, incidence of acute gouty arthritis, acanthosis nigricans, hyperglycemia, increased vasodilation and cystoid edema of the macula. It may also cause furunculosis and other skin lesions, hypotension, abdominal cramps, mild diabetes and urticaria. Other symptoms include pruritus, toxic amblyopia, jaundice and decreased glucose tolerance. ACUTE/CHRONIC HAZARDS: This compound may cause mild irritation to the upper respiratory tract. When heated to decomposition it may emit toxic fumes of NOx. (NTP, 1992)

4.3Indication of immediate medical attention and special treatment needed, if necessary

Immediate withdrawal of niacin is the primary treatment in acute toxicity. Symptoms should resolve over several hours with sequelae. Aspirin or nonsteroidal antiinflammatory drugs can be used for symptoms. For chronic toxicity treatment, niacin should be stopped and attention given to presenting symptoms and findings. Patients with significant hepatotoxicity may require intensive care monitoring and supportive care until liver function recovers. ... Treatment of rhabdomyolysis includes monitoring of renal function, urinary alkalinization, and maintenance of urinary output.

SECTION 5: Fire-fighting measures

5.1Suitable extinguishing media

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

5.2Specific hazards arising from the chemical

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

5.3Special protective actions for fire-fighters

Use water spray, foam, powder, carbon dioxide.

SECTION 6: Accidental release measures

6.1Personal precautions, protective equipment and emergency procedures

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.2Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

7.1Precautions for safe handling

NO open flames. Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2Conditions for safe storage, including any incompatibilities

Store in an area without drain or sewer access. Separated from strong acids, bases and oxidants.

SECTION 8: Exposure controls/personal protection

8.1Control parameters

Occupational Exposure limit values

Component Nicotinic acid
CAS No. 59-67-6
  Limit value - Eight hours Limit value - Short term
  ppm mg/m3 ppm mg/m3
Latvia   1    
  Remarks

 

Biological limit values

no data available

8.2Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear safety goggles.

Skin protection

Protective gloves.

Respiratory protection

Avoid inhalation of dust.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state

Solid. Powder.

Colour

White.

Odour

Odorless

Melting point/freezing point

236.6 °C.

Boiling point or initial boiling point and boiling range

Remarks:No boiling point determined. The substance sublimes at temperatures > 236.6 °C.

Flammability

Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

Lower and upper explosion limit/flammability limit

no data available

Flash point

193°C

Auto-ignition temperature

Remarks:No self-heating observed up to sublimation at ca. 250 °C.

Decomposition temperature

no data available

pH

pH = 2.7 (saturated aq soln)

Kinematic viscosity

no data available

Solubility

>18.5 [ug/mL]

Partition coefficient n-octanol/water

log Pow = -0.59. Temperature:25 °C.;log Pow = -2.34. Temperature:25 °C.

Vapour pressure

5.70X10-6 mm Hg at 25 deg C (est)

Density and/or relative density

1.473 g/cm³. Temperature:25 °C.

Relative vapour density

no data available

Particle characteristics

no data available

SECTION 10: Stability and reactivity

10.1Reactivity

On combustion, forms toxic gases including nitrogen oxides. Reacts with oxidants, strong acids and bases.

10.2Chemical stability

Stable in air

10.3Possibility of hazardous reactions

Dust explosion possible if in powder or granular form, mixed with air.NICOTINIC ACID is incompatible with strong oxidizers. It is also incompatible with sodium nitrite. (NTP, 1992)

10.4Conditions to avoid

no data available

10.5Incompatible materials

Dust explosion. Avoid contact with strong acids, alkaline solutions and oxidizing agents.

10.6Hazardous decomposition products

When heated to decomposition it emits toxic fumes of nitroxides.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 - rat (male) - 5 210 mg/kg bw.
  • Inhalation: LC50 - rat (male/female) - > 3.8 mg/L air (analytical).
  • Dermal: LD50 - rat (male/female) - > 2 000 mg/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

The substance is mildly irritating to the eyes.

STOT-repeated exposure

no data available

Aspiration hazard

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

SECTION 12: Ecological information

12.1Toxicity

  • Toxicity to fish: LC50 - Salmo trutta - 520 mg/L - 96 h.
  • Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 77 mg/L - 48 h.
  • Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 89.933 mg/L - 72 h.
  • Toxicity to microorganisms: EC10 - Pseudomonas putida - 88 mg/L - 16 h.

12.2Persistence and degradability

AEROBIC: In aqueous, aerobic soil suspensions containing mineral salts and a fertile garden soil inoculum, nicotinic acid was completely degraded after 2 to 4 days of incubation(1). In aqueous, aerobic soil suspensions containing a silt loam soil inoculum, nicotinic acid was degraded by 16.1% after 1 day, 99.9% after 2 days, and 100% after 4 days of incubation(2). Nicotinic acid was readily biodegraded in screening tests using an activated sludge inoculum(3).

12.3Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for nicotinic acid(SRC), using a log Kow of 0.36(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4Mobility in soil

The Koc of nicotinic acid is estimated as 37(SRC), using a log Kow of 0.36(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that nicotinic acid is expected to have very high mobility in soil. The pKa of nicotinic acid is 4.75(4), indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5Other adverse effects

no data available

SECTION 13: Disposal considerations

13.1Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

14.1UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.2UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.3Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.4Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.5Environmental hazards

ADR/RID: No IMDG: No IATA: No

14.6Special precautions for user

no data available

14.7Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

15.1Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Nicotinic acid Nicotinic acid 59-67-6 200-441-0
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.
Korea Existing Chemicals List (KECL) Listed.

SECTION 16: Other information

Information on revision

Creation Date July 15, 2019
Revision Date July 15, 2019

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

 

Package&Shipping

Details:

Qingdao Bravery International Trading Co., LTD. is located in the beautiful tourist city of Qingdao, is a comprehensive chemical enterprise which doing import and export business. Product range including, API, pharmacy intermediates,food additive,Surfactant ,fungicides and other general chemicals. etc.

With the developing world market, we adhere to the principle of "quality, service, integrity and development" ,Forge ahead,and constantly in pursuit of higher level of product quality and service.

We warmly welcome customers home and abroad to build mutual trust, mutual benefit and stable cooperation relation.

 

General items: import and export of goods; Technology import and export; Food additive sales; Feed additive sales; Sales of special chemical products (without hazardous chemicals); Sales of chemical products (excluding licensed chemical products); Livestock and fishery feed sales; Feed raw material sales; Fertilizer sales; Sales of bio-based materials; Health food (pre-packaged) sales; Food sales (pre-packaged food only); Sales of agricultural and sideline products; Pharmaceutical excipients sales; Drug wholesale

 

 

We could give you:

1.Best quality in your requirement

2.Competitive price in China market with standard high quality or customize

3.mature Technical support,Well-trained and professional technologist and sales with rich experience in the field for 5-10 years

4.Professional logistic support,Free sample and correct shipping documents dispatched according to regulations of different countries

All we want is win-win business. Send your inquiries, you will get it!

 

Why choose us:

1.Factory direct sales, so we can provide the competitive price and high quality product base on 5 years of production and R&D experience

2.It is available in stock for quick shipment. Products could be packaged according to customer’s specialized requirements.

3.The products can be transported by Courier, air or sea.

4.Customers will receive the most professional technical support and efficient service.

5.Any inquiries will be replied within 24hours.

6.High purity with test report.

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